Clinical Practice: Giant Cell Tumour of the Jaw Mimicking Bone Malignancy on Three-Dimensional Computed Tomography (3D CT) Reconstruction

Alessandro Lanza1, 2, Luigi Laino2, Luigi Rossiello3, Letizia Perillo2, Antonio Dell Ermo2, Nicola Cirillo1, 4, *
1 Regional Center on Craniofacial Malformations-MRI, Section of Genetic Oral Diseases
2 Department of Odontostomatology, and , 1st School of Medicine and Surgery, II University of Naples, 80138 Naples, Italy
3 Department of Dermatology, 1st School of Medicine and Surgery, II University of Naples, 80138 Naples, Italy
4 Department of Experimental Medicine, 1st School of Medicine and Surgery, II University of Naples, 80138 Naples, Italy

Article Metrics

CrossRef Citations:
Total Statistics:

Full-Text HTML Views: 541
Abstract HTML Views: 122
PDF Downloads: 195
Total Views/Downloads: 858
Unique Statistics:

Full-Text HTML Views: 274
Abstract HTML Views: 87
PDF Downloads: 159
Total Views/Downloads: 520

Creative Commons License
© Lanza et al.; Licensee Bentham Open.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the Department of Odontostomatology, Second University of Naples, Via Luigi de Crecchio, 7, 80138 Naples, Italy; E-mail:


A wide range of diseases may present with radiographic features of osteolysis. Periapical inflammation, cysts and benign tumours, bone malignancies, all of these conditions may show bone resorption on radiograph. Features of the surrounding bone, margins of the lesion, and biological behaviour including tendency to infiltration and root resorption, may represent important criteria for distinguishing benign tumours from their malign counterpart, although the radiographic aspect of the lesion is not always predictive. Therefore a critical differential diagnosis has to be reached to choose the best management. Here, we report a case of giant cell tumour (GCT) whose radiological features by computed tomography (CT) suggested the presence of bone malignancy, whereas the evaluation of a routine OPT scan comforted us about the benign nature of the lesion. A brief review of the literature on such a benign but locally aggressive neoplasm is also provided.