Carbonyl Reductase 3 (CBR3) Mediates 9-cis-Retinoic Acid-Induced Cytostatis and is a Potential Prognostic Marker for Oral Malignancy
Shuri Ohkura-Hada1, 2, Nobuo Kondoh1, 5, *, Akiyuki Hada1, Masaaki Arai1, Yutaka Yamazaki3, Masanobu Shindoh4, Yoshimasa Kitagawa3, Masayuki Takahashi2, Toshifumi Ando2, Yasunori Sato2, Mikio Yamamoto1
Identifiers and Pagination:Year: 2008
First Page: 78
Last Page: 88
Publisher ID: TODENTJ-2-78
Article History:Received Date: 19/2/2008
Revision Received Date: 19/3/2008
Acceptance Date: 9/5/2008
Electronic publication date: 09/6/2008
Collection year: 2008
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
The molecular mechanisms of growth suppression by retinoic acid (RA) were examined. Our results suggest that the cytostatic effects of RA could be mediated by the activation of endogenous CBR3 gene in oral squamous cell carcinomas (OSCCs), and the expression is a potential marker for oral malignancy.