RESEARCH ARTICLE
Carbonyl Reductase 3 (CBR3) Mediates 9-cis-Retinoic Acid-Induced Cytostatis and is a Potential Prognostic Marker for Oral Malignancy
Shuri Ohkura-Hada1, 2, Nobuo Kondoh1, 5, *, Akiyuki Hada1, Masaaki Arai1, Yutaka Yamazaki3, Masanobu Shindoh4, Yoshimasa Kitagawa3, Masayuki Takahashi2, Toshifumi Ando2, Yasunori Sato2, Mikio Yamamoto1
Article Information
Identifiers and Pagination:
Year: 2008Volume: 2
First Page: 78
Last Page: 88
Publisher ID: TODENTJ-2-78
DOI: 10.2174/1874210600802010078
Article History:
Received Date: 19/2/2008Revision Received Date: 19/3/2008
Acceptance Date: 9/5/2008
Electronic publication date: 09/6/2008
Collection year: 2008

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The molecular mechanisms of growth suppression by retinoic acid (RA) were examined. Our results suggest that the cytostatic effects of RA could be mediated by the activation of endogenous CBR3 gene in oral squamous cell carcinomas (OSCCs), and the expression is a potential marker for oral malignancy.