RESEARCH ARTICLE


Carbonyl Reductase 3 (CBR3) Mediates 9-cis-Retinoic Acid-Induced Cytostatis and is a Potential Prognostic Marker for Oral Malignancy



Shuri Ohkura-Hada1, 2, Nobuo Kondoh1, 5, *, Akiyuki Hada1, Masaaki Arai1, Yutaka Yamazaki3, Masanobu Shindoh4, Yoshimasa Kitagawa3, Masayuki Takahashi2, Toshifumi Ando2, Yasunori Sato2, Mikio Yamamoto1
1 Department of Biochemistry, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi
2 Department of Oral surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi
3 Department of Oral Diagnosis, Hokkaido University Graduate School of Dental Medicine, Sapporo-shi
4 Department of Oral Pathology and Diagnosis, Hokkaido University Graduate School of Dental Medicine, Sapporo-shi
5 Department of Biochemistry, Asahi University School of Dentistry, 1851 Hozumi, Mizuho-shi, Japan


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© Ohkura-Hada et al.; Licensee Bentham Open.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the Department of Biochemistry, Asahi University School of Dentistry, 1851 Hozumi, Mizuho-shi, Gifu-ken, 501-0296, Japan E-mail: nkondoh@dent.asahi-u.ac.jp


Abstract

The molecular mechanisms of growth suppression by retinoic acid (RA) were examined. Our results suggest that the cytostatic effects of RA could be mediated by the activation of endogenous CBR3 gene in oral squamous cell carcinomas (OSCCs), and the expression is a potential marker for oral malignancy.