A New Natural Antimycotic Agent is Effective Against Oropharyngeal Candidiasis: The VIPROCAN Study

Josefa Carrión-Navarro1, Alejandra Argüelles2, María Lara Martínez-Gimeno3, Alejandro Tovar Lozada4, Angel Ayuso-Sacido1, 5, Cristobal Belda-Iniesta6, Mercedes Arnás-Rodríguez4, Noemí García-Romero1 , *
1 Faculty of Experimental Sciences, Universidad Francisco de Vitoria, 28223 Madrid, Spain.
2 Vitalgaia España, S.L. 30005 Murcia, Spain
3 Department of Nursing, San Juan de Dios Foundation, San Rafael-Nebrija Health Sciences Center, Nebrija University, 28036 Madrid, Spain
4 Department of Dentistry, Hospital Universitario Sanchinarro, HM Hospitales, 28050 Madrid, Spain
5 Brain tumor laboratory, Fundación Vithas, Grupo Hospitales Vithas, 28043 Madrid, Spain
6 Institute of Health Carlos III. Ministry of Science. 28029 Madrid, Spain

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© 2022 Carrión-Navarro et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Faculty of Experimental Sciences, Universidad Francisco de Vitoria, 28223 Madrid, Spain; Tel: +34-609617144; E-mail:



The incidence of community and nosocomial candidiasis has dramatically increased in the last two decades. There are multiple treatments for this infection, but the toxicity of some and the induction of resistant strains require the development of new compounds.


With the aim of reducing the Candida population in the oropharyngeal cavity, we have formulated a toothpaste with VG-01 agent, composed of a mixture of carnosic acid (CA) and propolis (PP).


We investigated the ability of VG-01 toothpaste to minimize and stabilize fungal presence in 21 patients diagnosed with clinical oropharyngeal candidiasis.


Our data indicate that VG-01 toothpaste showed an effect not only against the most frequent species of Candida, C. albicans, but also in the other species analyzed. 82% of patients stated that they would continue using it outside the study.


Our data demonstrate that VG-01, composed of CA and PP is a potential antimycotic agent effective against the most common species that cause oropharyngeal candidiasis present in clinical practice.

Keywords: Oral health, Candida, Oropharyngeal candidiasis, Antimycotic effect, Antifungal, Toothpaste.