Quality of Life in Fibromyalgia Patients with Craniomandibular Disorders

D Di Venere , M Corsalini*, 1, G Stefanachi 1, S Tafuri 2, M De Tommaso 2, F Cervinara 1, A Re 1, F Pettini 1
1 Dental School, University of Bari, Bari, Italy
2 Department of Biomedical Sciences and Human Oncology, University of Bari, Bari, Italy

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© Di Venere et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Dental School, Universi-ty of Bari, Bari, Italy; Tel: (+39) 338-2062803; E-mail:


Fibromyalgia (FM) is a rheumatic disease which affects fibrous tissues and muscles; it is characterized by chronic pain and it is often associated with craniomandibular disorders (CMD). 31 patients were assessed from March 2012 to October 2012 through the administration of specific questionnaires and following neurologic and gnatologic assessment. A relevant corre-lation between FM and CMD emerges from the present study, as 80.6% of our patients report CMD symptoms with high prevalence of myofascial pain (84%). Multivariate regression analysis revealed that the patients in the present study did not differ in score of quality of life questionnaires from patients with fibromyalgia. The neuropathic pain diagnostic question-naire (DN4) scores were positively affected by belonging to group II of Research Diagnostic Criteria of Temporomandibular Disorders (RDC/ TDM) classification, suggesting the possibility of a neuropathic component in chronic pain in this CMD group, as already speculated in our study on the correlation between burning mouth syndrome and CMD and by other au-thors in studies on chronic low back pain. However, further clinic and instrumental studies are needed in order to test this as-sumption.

Keywords: Craniomandibular disorders, fibromyalgia, multivariate regression, myofascial pain, quality of life, temporomandibular disor-ders.