RESEARCH ARTICLE

Dentinal Tubule Disinfection with Propolis & Two Extracts of Azadirachta indica Against Candida albicans Biofilm Formed on Tooth Substrate

The Open Dentistry Journal 12 Nov 2015 RESEARCH ARTICLE DOI: 10.2174/1874210601509010369

Abstract

Aim:

This study evaluates the disinfection of dentinal tubules using Propolis, Azadirachta indica (alcoholic and aqueous extracts), 2% chlorhexidine gel and calcium hydroxide against Candida albicans biofilm formed on tooth substrate.

Materials & Method:

One hundred and five human teeth were infected with Candida albicans for 2 days. Samples were divided into 7 groups. Group I- Propolis, Group II- Alcoholic extract of Azadirachta indica, Group III- Aqueous extract of Azadirachta indica, Group IV- 2% Chlorhexidine, Group V- Calcium hydroxide, Group VI- Ethanol and Group VII- Saline (negative control). At the end of 1,3 and 5 days, the antimicrobial efficacy of medicaments against Candida albicans was assessed at the depths of 200 µm and 400 µm.

Results:

The overall percentage inhibition of fungal growth (at 200 µm and 400 µm depth) was 99.2% with 2% chlorhexidine gel. There was no statistical difference between propolis, alcoholic extract of Azadirachta indica (neem) and 2% chlorhexidine.

Conclusion:

Propolis and alcoholic extract of Azadirachta indica performed equally well as that of 2% Chlorhexidine.

Keywords:: Azadirachta indica, calcium hydroxide, Candida albicans, chlorhexidine, dentinal tubule disinfection, propolis.
Fulltext HTML PDF
1800
1801
1802
1803
1804