Mechanisms of Guided Bone Regeneration: A Review

Jie Liu#, David G Kerns*
Department of Periodontics, Baylor College of Dentistry, Texas A&M University, Dallas, TX

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© Liu and Kerns; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

# Private Practice, Houston, TX* Address correspondence to this author at the Texas A&M University, Baylor College of Dentistry, Department of Periodontics, 3302 Gaston Ave. Dallas, TX 75246; Tel: 214-828-8282; Fax: 214-874-4563; E-mail:


Post-extraction crestal bone resorption is common and unavoidable which can lead to significant ridge dimensional changes. To regenerate enough bone for successful implant placement, Guided Bone Regeneration (GBR) is often required. GBR is a surgical procedure that uses barrier membranes with or without particulate bone grafts or/and bone substitutes. There are two approaches of GBR in implant therapy: GBR at implant placement (simultaneous approach) and GBR before implant placement to increase the alveolar ridge or improve ridge morphology (staged approach). Angiogenesis and ample blood supply play a critical role in promoting bone regeneration.

Keywords: Bone regeneration, implant, ridge augmentation.