Glandular Odontogenic Cyst: Review of Literature and Report of a New Case with Cytokeratin-19 Expression

Marco Mascitti 1, *, Andrea Santarelli 1, 2, Antonio Sabatucci 1, Maurizio Procaccini 1, 2, Lorenzo Lo Muzio 3, Antonio Zizzi 4, Corrado Rubini 4
1 Department of Clinic Specialistic and Odontostomatological Sciences, Polytechnic University of Marche, Ancona, Italy
2 Institute of Health and Science on Aging INRCA, Ancona, Italy
3 Department of Sperimental and Clinical Medicine, University of Foggia, Foggia, Italy
4 Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy

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© Mascitti et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Clinic Specialistic and Odontostomatological Sciences, Polytechnic University of Marche, Ancona, Italy; Tel: +39-071-2206226; Fax: +39-071-2206221; E-mail:


The glandular odontogenic cyst (GOC) was a rare jawbone cyst described in 1988 as a distinct entity. This lesion can involve either jaw, and the anterior region of the mandible was the most commonly affected area. Clinical and radiographic findings were not specific, and the diagnosis of GOC can be extremely difficult due to the rarity of this lesion. The cyst presented a wall constituted by fibrous connective tissue and was lined by a non-keratinized stratified squamous epithelium of variable thickness. Large areas of the lining epithelium presented cylinder cells, sometimes ciliated. A variable amount of mucina was occasionally noted. Due to the strong similarities, this cyst can be easily misdiag-nosed as a central mucoepidermoid carcinoma (CMEC). Immunohistochemistry may be an aid in diagnosis; in fact has been demonstrated that there were differences in the expression of cytokeratins (CK) in GOC and CMEC. In this study, we reported a new case of GOC in a 38 year female patient. In addition, we carried out a review of 110 previous cases reported in literature.

Keywords: Cytokeratins, Glandular odontogenic cyst, Odontogenic cyst.