RESEARCH ARTICLE


Bone Formation with Two Types of Grafting Materials: A Histologic and Histomorphometric Study



Amir Reza Rokn1, 2, Mohammad Amin Khodadoostan3, Amir Ali Reza Rasouli Ghahroudi4, Puria Motahhary5, Mohammad Javad Kharrazi Fard6, Hugo De Bruyn7, Rose Afzalifar8, Ehsan Soolar9, Ahmad Soolari10, *
1 Associate Professor, Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
2 Associate Professor, Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran
3 Assistant Professor, Department of Periodontics, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran
4 Assistant Professor, Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
5 Assistant Professor, Department of Oral Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
6 Statistical Consultant, Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran
7 Professor and Chairman, Department of Periodontology and Oral Implantology, Dental School, Faculty of Medicine and Health Sciences, University Ghent Belgium, Ghent, Belgium
8 Dentist, Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran
9 College of Chemical and Life Science, University of Maryland, MD USA
10 Diplomate of American Board of Periodontology, Private practice, Silver Spring, MD, USA


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Creative Commons License
© Rokn et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the 11616 Toulone Dr., Potomac, MD 20854; Tel: 301 674-9815; Fax: 240 845 1087; E-mail: asoolari@gmail.com


Abstract

Background:

Although autogenous bone grafts are considered the gold standard for bone regeneration, they have certain limitations, including patient morbidity at the harvest site. Synthetic bone substitutes have been developed to overcome some of these limitations. The present study aimed to compare the osteogenic properties of Straumann Bone Ceramic (SBC), which is a biphasic calcium phosphate, with Bio-Oss, an inorganic bovine bone material, in an animal model.

Methods:

Thirteen rabbits were included in this study. In each rabbit, four 6.5-mm-diameter identical defects were prepared on the calvarium. One site was filled with Bio-Oss, the second site was treated with small-particle SBC, the third site was treated with large-particle SBC, and the fourth site was left as an untreated control. After 4 and 8 weeks, the animals were sacrificed, and histologic and histomorphometric examinations were performed. The data were analyzed using Friedman and multiple-comparison Mann-Whitney U tests.

Results:

There were no statistically significant differences in the amount of bone fill between the four groups. L-SBC showed more inflammation and foreign-body reactions than the other bone substitutes.

Conclusion:

No statistically significant differences were found between groups. Further studies on this issue seem necessary.

Keywords: Bone transplantation, bone ceramics, inorganic bovine bone mineral, animal study.