RESEARCH ARTICLE
Bone Formation with Two Types of Grafting Materials: A Histologic and Histomorphometric Study
Amir Reza Rokn1, 2, Mohammad Amin Khodadoostan3, Amir Ali Reza Rasouli Ghahroudi4, Puria Motahhary5, Mohammad Javad Kharrazi Fard6, Hugo De Bruyn7, Rose Afzalifar8, Ehsan Soolar9, Ahmad Soolari10, *
Article Information
Identifiers and Pagination:
Year: 2011Volume: 5
First Page: 96
Last Page: 104
Publisher ID: TODENTJ-5-96
DOI: 10.2174/1874210601105010096
Article History:
Received Date: 4/10/2010Revision Received Date: 16/2/2011
Acceptance Date: 5/4/2011
Electronic publication date: 7/7/2011
Collection year: 2011

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Abstract
Background:
Although autogenous bone grafts are considered the gold standard for bone regeneration, they have certain limitations, including patient morbidity at the harvest site. Synthetic bone substitutes have been developed to overcome some of these limitations. The present study aimed to compare the osteogenic properties of Straumann Bone Ceramic (SBC), which is a biphasic calcium phosphate, with Bio-Oss, an inorganic bovine bone material, in an animal model.
Methods:
Thirteen rabbits were included in this study. In each rabbit, four 6.5-mm-diameter identical defects were prepared on the calvarium. One site was filled with Bio-Oss, the second site was treated with small-particle SBC, the third site was treated with large-particle SBC, and the fourth site was left as an untreated control. After 4 and 8 weeks, the animals were sacrificed, and histologic and histomorphometric examinations were performed. The data were analyzed using Friedman and multiple-comparison Mann-Whitney U tests.
Results:
There were no statistically significant differences in the amount of bone fill between the four groups. L-SBC showed more inflammation and foreign-body reactions than the other bone substitutes.
Conclusion:
No statistically significant differences were found between groups. Further studies on this issue seem necessary.