RESEARCH ARTICLE


Oral Inflammatory Myofibroblastic Tumor: Case Report and Review of Literature



Nada O Binmadi a, *, Harold Packman b, John C Papadimitriou c, Mark Scheper a
a Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland, Baltimore, USA
b General Dentist, Private practice
c Department of Pathology, University of Maryland, Baltimore School of Medicine


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Creative Commons License
© Binmadi et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Oral and Maxillofacial Pathology, Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland, 650 W. Baltimore St, 7 North, Baltimore, 21201 MD, USA; Tel: 410 706 1655; Fax: 410 706 0519; E-mail: nbinm001@umaryland.edu


Abstract

Inflammatory myofibroblastic tumor (IMT) is a rarely described tumor of unknown etiology and pathogenesis. It occurs primarily in the lungs, but has occurred in other extra-pulmonary sites. Histologically these lesions appear as an inflammatory infiltrate within a variably myofibrotic background. Current evidence shows that inflammatory myofibroblastic tumors are neoplastic processes resulting from chromosomal translocations that often cause an overexpression of ALK kinase, which is often assessed using immunohistochemical studies. Currently, the biological behavior of oral inflammatory myofibroblastic tumor is still uncertain. This article describes the clinical, histological, and operative features of a case of IMT of the oral cavity.

Keywords: Inflammatory myofibroblastic tumor, inflammatory pseudotumor, oral cavity.