Histomorphometric Evaluation of Anorganic Bovine Bone Coverage to Reduce Autogenous Grafts Resorption: Preliminary Results

Carlo Maiorana1, Mario Beretta1, Giovanni Battista Grossi1, Franco Santoro1, Alan Scott Herford2, Heiner Nagursky3, Marco Cicciù4, *
1 Oral Surgery and Implantology, University of Milan, School of Dentistry, IRCSS Cà Granda, Milan, Italy
2 Oral and Maxillofacial Surgery Department, Loma Linda University, Loma Linda, California US
3 Hard Tissue Research Laboratory, Department for Oral- and Maxillofacial Surgery, University Hospital Freiburg, Freiburg, Germany
4 Dental Clinic, University of Messina, School of Dentistry, Italy

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© Maiorana et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Oral Surgery and Implantolgy, University of Milan School of Dentistry, Italy; Tel: 00390255032621; Fax: 00390255032513; E-mail:


Physiologic resorption due to remodeling processes affects autogenous corticocancellous grafts in the treatment of atrophic jawbone alveolar ridges. Such a situation in the past made overgrafting of the recipient site mandatory to get enough bone support to dental implants in order to perform a prosthetic rehabilitation. Anorganic bovine bone, conventionally used to treat alveolar bone deficiencies in implant surgery, showed a high osteoconductive property thanks to its micro and macrostructure very similar to that of human hydroxyapatite. An original technique provides for the application of a thin layer of anorganic bovine bone granules and a collagen membrane on the top of the corticocancellous onlay bone grafts to reduce in a remarkable way the graft resorption due to remodeling. The results of a clinical prospective study and a histomorphometric analysis done on autogenous grafts harvested from the iliac crest showed that the proposed technique is able to maintain the original bone volume of the corticocancellous blocks.

Key Words: Bone graft, bone remodelling, bone regeneration.