Closure of an Open Wound Associated with Bisphosphonate-Related Osteonecrosis of the Jaw in a Breast Cancer Patient

Nafiseh Soolari 1, Ahmad Soolari 2, *
1 Department of Communication, College of Arts and Humanities, University of Maryland, College Park, MD, USA
2 Private Practice in Periodontology, Silver Spring and Potomac, MD, USA

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© Soolari and Soolari; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the 11616 Toulone Drive. Potomac, MD 20854, USA; Tel: 301 674-9815; Fax: 240-845-1087; E-mail:


Background and Objective:

Many clinicians will not treat patients presenting with bisphosphonate-related osteonecrosis of the jaw following long-term use of bisphosphonates because of the lack of predictable outcomes.

Materical and Methods:

The patient presented with pain from a nonhealing lesion in the posterior maxilla following extraction of the maxillary right third molar. The lesion had not responded to any conventional dental treatment. The patient had suffered from breast cancer, and her treatment included several years of therapy with Zometa (zoledronic acid), a bisphosphonate.


The patient stopped taking Zometa and commenced rinsing with phosphate buffer–stabilized 0.1% chlorine dioxide–containing mouthwash. After 5 months, changes in the morphology of the lesion were noted and the soft tissue had closed over the open wound.


Cessation of bisphosphonate therapy and usage of a phosphate buffer–stabilized 0.1% chlorine dioxide–containing mouthwash lessened the patient’s pain and resulted in closure of the soft tissue lesion.

Keywords: Bisphosphonate, Zometa, Osteonecrosis of the Jaw, Breast cancer, Cancer.