Multidisciplinary Rehabilitation Approach to the Maxillo-Facial Complications of Crouson’s Disease: Case Report and Review

Hattan A. Zaki1, Muath Saad Alassaf1, 3, Hamzah Ali Babkair1, Ghada A. Abdel-Latif1, 2, Abdulrahman Khaled Jaffar4, Albraa B. Alolayan3, Shadia Abdel-Hameed Elsayed3, 5, *
1 Department of Oral Basic and Clinical Sciences, College of Dentistry, Taibah University, Almadinah Almunawwarah, Saudi Arabia
2 Department of Oral Pathology, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt
3 Department of Oral and Maxillofacial Surgery, Taibah University Dental College & Hospital, Al-Madinah Al-Munawwrah, Saudi Arabia
4 Yanbu National Hospital, Yanbu, Saudi Arabia
5 Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine for Girls, Al-Azhar University. Cairo, Egypt

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© 2022 Zaki et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Taibah University, College of Dentistry, Almadinah Almunawwarrah, 344/41411, Saudi Arabia; E-mail:



Craniofacial anomalies present a challenge to all health care practitioners since they necessitate long-term team follow-up, which is difficult to achieve outside of a major center where craniofacial anomalies teams normally collaborate.


The current review with an illustrative case focuses on the representation and review of Crouzon syndrome and its maxillofacial implications. Review of different varieties of gene mutations that produce craniosynostosis syndromes were discussed and focused on seven clinically distinct craniosynostosis syndromes that are precipitated by the mutation in one or more of the fibroblast growth factor receptors genes which affected the maxillofacial region.

Case presentation:

A complete clinical and radiographic case scenario of a patient suffering from Crouzon syndrome was presented, and discussion of the various disciplines and techniques used along the way to achieve the best results, as well as how team collaboration and patient compliance led to the best results were represented. The presented case was treated with orthodontic treatment, Le Fort-I osteotomy, and Le Fort-III osteotomy with extraoral distraction osteogenesis.


The combination of different orthognathic surgery alternatives (Le Fort-III and Le Fort-I) with distraction osteogenesis and orthodontic treatment produced excellent outcomes with few complications, and the patient was extremely satisfied and cooperative. Early and thorough team-based care for Crouzon syndrome patients should be accessible at specialized craniofacial centers.

Keywords: Craniosynostosis, Crouzon, Maxillofacial, Dental implication report, CRS, Osteotomy.