Is Conservative Surgery the Best Approach for Peripheral Calcifying Epithelial Odontogenic Tumors?

Isadora Luana Flores1, *, Tissiana Rachel Rossi Schneider2, Ana Carolina Uchoa Vasconcelos2, Sandra Beatriz Chaves Tarquinio2, Ricardo Alves de Mesquita3, Ana Paula Neutzling Gomes2
1 Department of Conservative Dentistry, Oral Pathology, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2492, Santa Cecília, Porto Alegre, RS, Brazil
2 Pelotas Dental School, Semiology and Clinic, Federal University of Pelotas, Rua Gonçalves Chaves, 457, Bairro Centro, Pelotas, RS, Brazil
3 Department of Oral Pathology and Surgery, Federal University of Minas Gerais, Belo Horizonte, Rua Prof Moacir Gomes de Freitas, 688, Bairro Pampulha, Belo Horizonte, MG, Brazil

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Creative Commons License
© 2018 Flores et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address Correspondence to this author at the Department of Conservative Dentistry, Oral Pathology, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2492, Bairro Santa Cecília, Porto Alegre, RS, Brazil. Zip Code: 90035-004; Tel: +55 51 3308 5011; E-mail:



Peripheral Calcifying Epithelial Odontogenic Tumors (CEOT) rich in clear cells are a rare entity in the oral cavity, with only 14 previous case reports in the English literature. None have discussed recommended treatment approaches for extraosseous CEOT.


This brief descriptive review describes a treatment approach for peripheral CEOT including the clear cell variant.

Study design:

A complete review of all well-documented extraosseous case reports with an emphasis on the treatment was performed. Additionally, the present article reports a case of a 21-year-old woman with an asymptomatic swelling in the gingiva finally diagnosed as peripheral CEOT abundant in clear cells.


Twenty-four cases of peripheral CEOT were described; conservative surgery was the first treatment approach in approximately 80% of cases, with only one recurrence.


Clear cell finding was not associated with more aggressive behavior.


Conservative surgery may be an advantageous approach for this group of peripheral lesions with or without clear cells, with a recurrence rate of approximately 4%.

Keywords: Calcifying epithelial odontogenic tumor, Clear cell, Peripheral, Oral diagnosis, Surgery, Treatment.