Evaluation of Effect of Low-Dose Methotrexate on Osseointegration of Implants: A Biomechanical Study on Dogs

Tavakoli, Mohamad; Yaghini, Jaber; abed, Ahmad Moghare; Malekzadeh, Meisam; Maleki, Dina

Evaluation of Effect of Low-Dose Methotrexate on Osseointegration of Implants: A Biomechanical Study on Dogs

Mohamad Tavakoli¹, Jaber Yaghini¹, Ahmad Moghare abed¹, Meisam Malekzadeh^{2, *}, Dina Maleki²

¹ Department of Periodontics, Isfahan University of Medical Sciences, Isfahan, Iran

² Department of Periodontics and Dental Sciences Research Center, Faculty of Dentistry, Guilan University of Medical Sciences, Rasht, Iran

Article Information

Identifiers and Pagination:

Year: 2018
Volume: 12
First Page: 546
Last Page: 554
Publisher ID: TODENTJ-12-546
DOI: 10.2174/1874210601812010546

Article History:

Received Date: 14/4/2018
Revision Received Date: 20/6/2018
Acceptance Date: 16/7/2018
Electronic publication date: 31/7/2018
Collection year: 2018

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© 2018 Tavakoli et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

^* Address correspondence to the author at the Department of Periodontics and Dental Sciences Research Center, Faculty of Dentistry, Guilan University of Medical Sciences, Rasht, Iran; Tel: 00989126180116; Fax: 00981344552334; E-mail: meymalekzadeh@gmail.com

Background:

Methotrexate (MTX) is an immunosuppressive drug, widely used in inflammatory disturbances including rheumatoid arthritis. However, there is no consensus regarding the effect of MTX on implant osseointegration.

Objective:

The purpose of this experimental study was to investigate the effect of low dose MTX on Bone-Implant Contact (BIC) of dogs.

Methods:

Six mandibular premolar teeth (bilateral) of 8 mature dogs were extracted. After 3 months of healing, 6 implants (bone level, resorbable blast media surface) were inserted into the mandible of each dog (3 in each side). Dogs were randomly divided into a study group (receiving 2.5 mg/week MTX orally, 3 times per week for 4 weeks) and a control group each containing 4 dogs. In the 1^st week, postoperative BIC was evaluated in 4 dogs, two from each group. In the 4^th week, reverse torque and BIC were evaluated in the remaining 4 dogs. Data were analyzed with two-way ANOVA test for 95% confidence interval.

Results:

The reverse torque test of the 4^th week, showed a satisfying osseointegration. Histopathologic evaluation revealed that the BIC was significantly higher in the control group in comparison to the MTX group in the 1^st and 4^th week. In addition, the BIC of both groups were significantly increased in the 4^th week in comparison to the 1^st week in both groups.

Conclusion:

MTX has the potential to interfere with osseointegration process.

Keywords: Methotrexate, Osseointegration, Dental implants, Rheumatoid arthritis, Bone-implant interface, Bone-implant contact.

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RESEARCH ARTICLE

Evaluation of Effect of Low-Dose Methotrexate on Osseointegration of Implants: A Biomechanical Study on Dogs

Article Information

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Article History:

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Total Statistics:

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Abstract

Background:

Objective:

Methods:

Results:

Conclusion:

Track Your Manuscript

Published Contents

About the Editor

About the Journal

The Open Dentistry Journal

Journal Metrics

Readership Statistics:

Total Views/Downloads: 772,777

Unique Views/Downloads: 112,093

Press Release

Bentham Open Welcomes Sultan Idris University of Education (UPSI) as Institutional Member

Ministry Of Health, Jordan joins Bentham Open as Institutional Member

Prof. Dileep Sharma joins the Editorial Board of The Open Dentistry Journal

Porto University joins Bentham Open as Institutional Member

Testimonials