Peripheral Odontogenic Myxoma: Report of Two New Cases with a Critical Review of the Literature

Marco Mascitti1, Lucrezia Togni1, Filippo Pirani2, *, Corrado Rubini3, Andrea Santarelli1, 4
1 Department of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, Ancona, Italy
2 Department of Dentistry, IRCCS San Raffaele Hospital and Dental School, Vita Salute University, Milan, Italy
3 Department of Biomedical Sciences and Public Health, Marche Polytechnic University, Ancona, Italy
4 National Institute of Health and Science of Aging, INRCA, 60126 Ancona, Italy

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© 2018 Mascitti et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Dentistry, IRCCS San Raffaele Hospital and Dental School, Vita Salute University, Milan, Italy / Via Giovanni Pascoli, 60020 Ancona - Italy; Tel: +39-071-2206219; Fax: +39-071-2206221; E-mail:



Odontogenic myxoma is a benign mesenchymal odontogenic tumor that is more frequently found in the mandibular molar region. The extra-osseous counterpart, called Peripheral Odontogenic Myxoma (POM), is an exceedingly rare entity and with very low aggressive potential.


Clinical and radiographic findings are not specific, and difficulties may exist in differentiating histological findings of POM from other tumors with myxoid features, such as fibromas and oral focal mucinosis. Due to the fact that the presence of odontogenic epithelium is not required for the diagnosis, a myxoid lesion without odontogenic nests that develops in extraosseous position can be misdiagnosed with a soft tissue myxoma.

Case Reports:

We thereby present two cases of POM and conduct an extensive and critical review of the English literature, taking into consideration both certain and putative cases of POM.

Keywords: Odontogenic myxoma, Peripheral odontogenic myxoma, Soft tissue myxoma, Odontogenic tumor, Odontogenic epithelium, Differential diagnosis.