RESEARCH ARTICLE


Reduction in Dental Hypersensitivity with Nano-Hydroxyapatite, Potassium Nitrate, Sodium Monoflurophosphate and Antioxidants#



Samuel B. Low1, 4, *, Edward P. Allen2, Elias D. Kontogiorgos3
1 Department of Periodontics, University of Florida College of Dentistry, University of Florida, Gainesville, Florida 32610, USA;
2 Department of Periodontics, Texas A&M University, Baylor College of Dentistry; Dallas, Texas 75246, USA;
3 Department of Restorative Sciences, Texas A&M, Baylor University, College of Dentistry, Dallas, Texas 75246, USA;
4 Department of Restorative Sciences, Texas A&M, Baylor University, College of Dentistry, Dallas, Texas 75246, USA;


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Creative Commons License
© Low et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Periodontics, University of Florida College of Dentistry, University of Florida, Gainesville, Florida 32610, USA; Tel: 352 538-9654; E-mail: slow@dental.ufl.edu
# Supported in part by Perio Sciences LLC


Abstract

Objective:

This clinical study aimed to evaluate effectiveness of a commercially available toothpaste containing potassium nitrate, sodium monoflurophosphate, and nano-hydroxyapatite as well as antioxidants phloretin, ferulic acid and silymarin in reducing dental hypersensitivity in adults.

Methods:

The clinical trial enrolled patients with a history of dentin hypersensitivity. A test toothpaste was introduced into the daily routine, which included initial instruction on usage. Patients completed a five-question visual analog scale (VAS) at the inception/baseline, after two days and after two weeks of using the toothpaste to determine their level of tooth sensitivity at baseline with the use of the toothpaste over time.

Results:

Patients that had significant sensitivity at baseline had a range of 52% to 76 % improvement after 48 hours and a range of 70% to 84% improvement after two weeks.

Conclusion:

A toothpaste containing potassium nitrate, sodium monoflurophosphate, and nano-hydroxyapatite plus antioxidants phloretin, ferulic acid and silymarin applied daily significantly decreased tooth pain of dentin hypersensitivity within a two-day and two-week time period.

Clinical Significance:

Based on the clinical study results, a daily application of a toothpaste containing potassium nitrate, sodium monofluorophosphate, and nano-hydroxyapatite plus antioxidants phloretin, ferulic acid and silymarin can significantly and quickly reduce tooth pain of dentin hypersensitivity.

Keywords: : Antioxidants, dentin hypersensitivity, hydroxyapatite, polyphenol.