This clinical study aimed to evaluate effectiveness of a commercially available toothpaste containing
potassium nitrate, sodium monoflurophosphate, and nano-hydroxyapatite as well as antioxidants phloretin, ferulic acid
and silymarin in reducing dental hypersensitivity in adults.
The clinical trial enrolled patients with
a history of dentin hypersensitivity. A test toothpaste was introduced into the daily routine, which included initial instruction
on usage. Patients completed a five-question visual analog scale (VAS) at the inception/baseline, after two days and
after two weeks of using the toothpaste to determine their level of tooth sensitivity at baseline with the use of the
toothpaste over time.
Patients that had significant sensitivity at baseline had a range of 52% to 76 % improvement
after 48 hours and a range of 70% to 84% improvement after two weeks.
A toothpaste containing potassium
nitrate, sodium monoflurophosphate, and nano-hydroxyapatite plus antioxidants phloretin, ferulic acid and silymarin
applied daily significantly decreased tooth pain of dentin hypersensitivity within a two-day and two-week time period.
Based on the clinical study results, a daily application of a toothpaste containing potassium nitrate,
sodium monofluorophosphate, and nano-hydroxyapatite plus antioxidants phloretin, ferulic acid and silymarin can significantly
and quickly reduce tooth pain of dentin hypersensitivity.
Keywords: : Antioxidants, dentin hypersensitivity, hydroxyapatite, polyphenol.