Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients

Kosuke Naganawa 1, 2, #, Eiji Takayama 1, #, Makoto Adachi 2, 3, #, Kenji Mitsudo 3, #, Masaki Iida 3, #, Masako Kamiya-Mizuno 1, Harumi Kawaki 1, Masao Ichinose 4, Masayuki Motohashi 2, Yasunori Muramatsu 2, Iwai Tohnai 3, Shin-Ichiro Sumitomo 2, Michio Shikimori 2, Nobuo Kondoh 1, *
1 Department of Oral Biochemistry, School of Dentistry, Asahi University, 1851 Hozumi, Mizuho, Gifu 501-0296, Japan
2 Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, 1851 Hozumi 1851-1, Mizuho-shi, Gifu 501-0296, Japan
3 Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Yokohama, Kanagawa 236-0004, Japan
4 Second Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, Japan

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© Naganawa et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Oral Biochemistry, School of Dentistry, Asahi University, 1851 Hozumi, Mizuho, Gifu 501-0296, Japan; Tel: +81-058-329-1416; Fax: +81-058-329-1417; E-mail:
# These authors contributed equally to this work.


In order to evaluate the Th1 and Th2 responses of Oral Squamous Cell Carcinoma (OSCC) patients, we investigated the cytokine producing capability of peripheral blood (PB), and compared it with clinicopathological appearances of OSCC patients. The production of a Th1-type cytokine, interferon (IFN)-γ, from lipopolysaccharide (LPS)-stimulated PB correlated positively with the frequency of lymph node metastasis. We also investigated the production of a Th2-type cytokine, IL-10, however, no significant correlation was observed with the clinicopathological appearances. Our results suggested that the IFN-γ producing capability was specifically regulated and dependent on the regional metastatic potencies of OSCCs.

Keywords: Cytokine-producing capability, interferon-gamma (IFN-γ), Oral squamous cell carcinoma, peripheral blood, tumor immunology.