Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients
Kosuke Naganawa 1, 2, #, Eiji Takayama 1, #, Makoto Adachi 2, 3, #, Kenji Mitsudo 3, #, Masaki Iida 3, #, Masako Kamiya-Mizuno 1, Harumi Kawaki 1, Masao Ichinose 4, Masayuki Motohashi 2, Yasunori Muramatsu 2, Iwai Tohnai 3, Shin-Ichiro Sumitomo 2, Michio Shikimori 2, Nobuo Kondoh 1, *
Identifiers and Pagination:Year: 2015
First Page: 120
Last Page: 124
Publisher Id: TODENTJ-9-120
Article History:Received Date: 12/1/2015
Revision Received Date: 26/2/2015
Acceptance Date: 3/3/2015
Electronic publication date: 31 /3/2015
Collection year: 2015
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
In order to evaluate the Th1 and Th2 responses of Oral Squamous Cell Carcinoma (OSCC) patients, we investigated the cytokine producing capability of peripheral blood (PB), and compared it with clinicopathological appearances of OSCC patients. The production of a Th1-type cytokine, interferon (IFN)-γ, from lipopolysaccharide (LPS)-stimulated PB correlated positively with the frequency of lymph node metastasis. We also investigated the production of a Th2-type cytokine, IL-10, however, no significant correlation was observed with the clinicopathological appearances. Our results suggested that the IFN-γ producing capability was specifically regulated and dependent on the regional metastatic potencies of OSCCs.