Expression of p27Kip1 and E-cadherin in Head and Neck Squamous Cell Carcinoma of Indonesian Patients
Auerkari E.I*, 1, 2, Joewono V3, Handjari D.R3, Sarwono A.T1, Suhartono A.W1, Eto K2, Ikeda M.A 2
Identifiers and Pagination:Year: 2014
First Page: 136
Last Page: 143
Publisher Id: TODENTJ-8-136
Article History:Received Date: 28/4/2014
Revision Received Date: 27/6/2014
Acceptance Date: 1/7/2014
Electronic publication date: 8/9/2014
Collection year: 2014
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Cancer cells exhibit characteristic damage of DNA and its expression. The expression of the tumor suppressors E-cadherin and p27Kip1 has been tested on 57 head and neck squamous cell carcinomas (HNSCC) of Indonesian subjects. HNSCC tumor samples including both primary and (unrelated) nodal cases were obtained from the archives of Indonesian hospitals, in accordance with acknowledged ethical requirements. Only modest correlation was found between reduced expression of E-cadherin or p27Kip1 with increased malignancy of primary and nodal growth. The observed strong correlation regardless of malignancy between the expressed levels of E-cadherin and p27Kip1 suggests that also in combination these would not help to better predict the outcome of HNSCC.