Expression of p27Kip1 and E-cadherin in Head and Neck Squamous Cell Carcinoma of Indonesian Patients

Auerkari E.I*, 1, 2, Joewono V3, Handjari D.R3, Sarwono A.T1, Suhartono A.W1, Eto K2, Ikeda M.A 2
1 Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Salemba Raya 4, Jakarta 10430, Indonesia
2 Department of Molecular Craniofacial Embryology, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8549 Japan
3 Department of Anatomic-Pathology, Faculty of Medicine, University of Indonesia, Salemba Raya 6, Jakarta 10430, Indonesia

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© Auerkari et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Salemba Raya No. 4, Jakarta 10430, Indonesia. Tel: 62-21-3910344; Fax: 62-21-3193 1412; E-mail:


Cancer cells exhibit characteristic damage of DNA and its expression. The expression of the tumor suppressors E-cadherin and p27Kip1 has been tested on 57 head and neck squamous cell carcinomas (HNSCC) of Indonesian subjects. HNSCC tumor samples including both primary and (unrelated) nodal cases were obtained from the archives of Indonesian hospitals, in accordance with acknowledged ethical requirements. Only modest correlation was found between reduced expression of E-cadherin or p27Kip1 with increased malignancy of primary and nodal growth. The observed strong correlation regardless of malignancy between the expressed levels of E-cadherin and p27Kip1 suggests that also in combination these would not help to better predict the outcome of HNSCC.

Keywords: E-cadherin, head and neck squamous cell carcinoma, p27Kip1.