Cancer cells exhibit characteristic damage of DNA and its expression. The expression of the tumor suppressors E-cadherin and p27Kip1 has been tested on 57 head and neck squamous cell carcinomas (HNSCC) of Indonesian subjects. HNSCC tumor samples including both primary and (unrelated) nodal cases were obtained from the archives of Indonesian hospitals, in accordance with acknowledged ethical requirements. Only modest correlation was found between reduced expression of E-cadherin or p27Kip1 with increased malignancy of primary and nodal growth. The observed strong correlation regardless of malignancy between the expressed levels of E-cadherin and p27Kip1 suggests that also in combination these would not help to better predict the outcome of HNSCC.
Keywords: E-cadherin, head and neck squamous cell carcinoma, p27Kip1.
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This work was partly (for EIA) financially supported by the Japan Society for the Promotion of Science and the University of Indonesia, and this support is gratefully acknowledged.
Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Salemba Raya 4, Jakarta 10430, Indonesia
Department of Molecular Craniofacial Embryology, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8549 Japan
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