RESEARCH ARTICLE


Fibroblastic Variant of Osteosarcoma: A Challenge in Diagnosis & Management



Dinkar Desai 1 , *, Siddharth Pandith 1, Prabhakar A Jeergal 1, K Arathi 1, Rajan Saini2
1 Department of Oral and Maxillofacial Pathology, A.J. Institute of Dental Sciences, Mangalore 575004, Karnataka, India
2 School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia


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© Desai et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Oral and Maxillofacial Pathology, A.J. Institute of Dental Sciences, Mangalore 575004, Karnataka, India; Tel: +91 9845263743; Fax: +91 08242225541; E-mail: dinkar22desai@gmail.com


Abstract

Osteosarcoma of the jaws is a relative rare malignant bone tumor. Like, its counterpart in the long bones, osteosarcoma affecting the head and neck region shows distinct yet diverse clinical, histologic and prognostic characteristics. Its diagnosis is a challenge to histopathologists and is especially important in early stages to improve its prognosis. In the initial phase, it may present as nondescript swelling with an indolent growth rate, only to become overtly aggressive and malignant towards the later phase of the disease. This article reports on a case of an advanced osteosarcoma of the maxilla in a 42 year old woman who came for the evaluation of a swelling. The case was submitted for surgical intervention and was followed by one recurrence till the time of reporting. This case illustrates that immunohistochemical staining of Vimentin, S-100 and CD 68 markers are useful to confirm the histologic diagnosis of osteosarcoma, along with radiographic evaluation using CT scan and 3D imaging.

Key Words: Osteosarcoma, fibroblastic, bone neoplasm, maxilla.