RESEARCH ARTICLE


Nasopharyngeal Carcinoma Metastatic to the Mandible



Po Hsien Huang1, Yih Chuen Shyng2 , P Sloan3 , Keng-Liang Ou4 , Y. J. Hsia5 , H. Devlin*, 6
1 Chief Resident of Kaoshiuang Military General Hospital, Taiwan
2 Head of Medical Research and Animal Study Unit, Kaohsiung Military General Hospital, 2 Chengchung 1st Rd., Kaohsiung Taiwan
3 School of Dentistry, University of Newcastle, UK
4 Graduate Institute of Oral Sciences, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
5 Head of Department of Oral and Maxillofacial Surgery, Tri-Service General Hospital, Taiwan
6 School of Dentistry, University of Manchester, Higher Cambridge St., Manchester M15 6FH, UK


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Creative Commons License
© Huang et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the School of Dentistry, University of Manchester, Higher Cambridge St., Manchester M15 6FH, UK; Tel: +44(0)-161-275-6849; Fax: +44(0)-161-275-6710; E-mail: Hugh.Devlin@Manchester.ac.uk


Abstract

Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in the head and neck region, especially among those of Chinese origin. NPC has multifactorial aetiologies including genetic susceptibility, consumption of food with high salt content, and the Epstein–Barr virus. The primary tumour usually arises from the lateral walls of the nasopharynx and is characterized by a rich sub-mucosal lymphatic structure, often leading to cervical lymph node metastasis. Distant metastasis has been recognized to be a major cause of treatment failure in patients with nasopharyngeal carcinoma. Bone, liver and lung are the most frequent sites of NPC metastases.

Keywords: Mandible, Nasopharyngeal carcinoma.