Salivary Markers for Oral Cancer Detection

Anastasios K. Markopoulos*, 1, Evangelia Z. Michailidou1, Georgios Tzimagiorgis2
1 Department of Oral Medicine/Pathology, School of Dentistry, Aristotle University, Thessaloniki, Greece
2 Department of Biological Chemistry, School of Medicine, Aristotle University, Thessaloniki, Greece

Article Metrics

CrossRef Citations:
Total Statistics:

Full-Text HTML Views: 275
Abstract HTML Views: 67
PDF Downloads: 53
Total Views/Downloads: 395
Unique Statistics:

Full-Text HTML Views: 179
Abstract HTML Views: 57
PDF Downloads: 51
Total Views/Downloads: 287

Creative Commons License
© Markopoulos et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Oral Medicine/Pathology, School of Dentistry, Aristotle University, 54124 Thessaloniki, Greece; Tel: +30 2310 999523; Fax: +30 2310 999532-E mail:


Oral cancer refers to all malignancies that arise in the oral cavity, lips and pharynx, with 90% of all oral cancers being oral squamous cell carcinoma. Despite the recent treatment advances, oral cancer is reported as having one of the highest mortality ratios amongst other malignancies and this can much be attributed to the late diagnosis of the disease. Saliva has long been tested as a valuable tool for drug monitoring and the diagnosis systemic diseases among which oral cancer. The new emerging technologies in molecular biology have enabled the discovery of new molecular markers (DNA, RNA and protein markers) for oral cancer diagnosis and surveillance which are discussed in the current review.

Keywords: OSCC, DNA, mRNA, miRNA.