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Carbonyl Reductase 3 (CBR3) Mediates 9-cis-Retinoic Acid-Induced Cytostatis and is a Potential Prognostic Marker for Oral Malignancy
Shuri Ohkura-Hada1 , 2
Nobuo Kondoh1 , 5 , *
Akiyuki Hada1
Masaaki Arai1
Yutaka Yamazaki3
Masanobu Shindoh4
Yoshimasa Kitagawa3
Masayuki Takahashi2
Toshifumi Ando2
Yasunori Sato2
Mikio Yamamoto1
Authors Info & Affiliations
Akiyuki Hada1
Masaaki Arai1
Yutaka Yamazaki3
Masanobu Shindoh4
Yoshimasa Kitagawa3
Masayuki Takahashi2
Toshifumi Ando2
Yasunori Sato2
Mikio Yamamoto1
Authors Info & Affiliations
Abstract
The molecular mechanisms of growth suppression by retinoic acid (RA) were examined. Our results suggest that the cytostatic effects of RA could be mediated by the activation of endogenous CBR3 gene in oral squamous cell carcinomas (OSCCs), and the expression is a potential marker for oral malignancy.
