RESEARCH ARTICLE


Comparison of Biocompatibility of Experimental Tricalcium Phosphate Cement versus Biodentin and Mineral Trioxide Aggregate used for Furcation Perforation Repair (in vivo study)



Mostafa M. El-Bialy1, *, Magdy M. Ali2, Engy M. Kataia1, Reham S. El Nemr3, Reham Hassan4, 5
1 Department of Restorative and Dental Materials, National Research Centre, Cairo, Egypt
2 Department of Endodontics, Faculty of Dentistry, Beni Suef University, Beni Suef, Egypt
3 Department of Pathology, Fayoum University, Faiyum, Egypt
4 Department of Endodontics, Faculty of Dentistry, Minia University, Minya, Egypt
5 Department of Endodontic, Egyptian-Russian University, Badr City, Egypt


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Creative Commons License
© 2021 El-Bialy et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Restorative and Dental Materials, National Research Centre, Cairo, Egypt; E-mail: mostafa.bialy@hotmail.com


Abstract

Background:

The interaction between the root canal system and the oral cavity caused by iatrogenic perforations significantly affects the treatment outcome and tooth survival.

Objectives:

This study was directed to compare the biocompatibility of an experimental tricalcium phosphate cement versus biodentine and mineral Trioxide aggregate used for furcation perforation repair in dogs.

Methods:

Perforations were done in 60 teeth (premolars and molars) of six adult dogs. Animals were divided randomly into 3 equal groups of 2 animals each according to the post-operative evaluation period of 1 week, 1 month, and 3-months. Each group was further subdivided into 4 subgroups according to either being repaired with the experimental tricalcium phosphate cement (n=6), or Biodentine (n=6), Mineral Trioxide Aggregate (MTA) (n=6), and positive control(n=2). After evaluation periods, tissue blocks were harvested and histologically examined.

Results:

No statistically significant difference was found regarding bone deposition scores and inflammatory reaction in the three groups after 1 week, 1 month, or 3 months. All three groups showed a statistically significant difference between all three time periods. Regardless of the repair material used, inflammation scores at 1-week showed the highest scores, decreasing over time except for the control group.

Conclusion:

The experimental material could be considered as a successful treatment option for repairing furcation perforation.

Keywords: Perforation repair, MTA, Biodentine, Experimental tricalcium phosphate cement, Control group, Dogs.