Unfinished root formation has always offered challenges in endodontics due to technical difficulties and weakened teeth resistance during the lifetime of an individual. Pulp revascularization therapy appeared as a solution for apical closure and root maturation. The existence of oral stem cells involved in the process associated with traditional resident cells requires adequate blood supply given by induced controlled injury deliberately accomplished into the periapical zone.
The aim of this work was to research, through literature review, the main mechanisms involved in the process of apical closure through the technique of pulp revascularization.
Apice closure in pulpless teeth seems to happen as a result of professional intervention and biological activity. The success rate depends on the role of traditional local immune cells and stem cells associated with adequate blood supply to finish root formation.
Keywords: Pulp revascularization, Apex closure, Endodontics, Oral stem cells, Apexogenesis, Angiogenesis.