Comparison of Benzydamine Hydrochloride Mouthwash 0.15% and Ibuprofen in Reducing Postoperative Pain during 24 hours after Crown Lengthening: a Randomized Clinical Trial

Arezoo Khabazian1, Ali Tavakoli2, Samane Soltani3, *, Elaheh Karami4, Niloofar Mohaghegh5
1 School of Dentistry,Department of Periodontology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 School of Dentistry,Department of Oral and Maxillofacial Pathology , Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3 School of Dentistry,Department of Periodontology, Isfahan University of Medical Sciences, Isfahan, Iran
4 Department of Periodontology, Omid Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
5 Private Practice, Dentistry, Yazd, Iran

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© 2020 Soltani et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the School of dentistry, Department of Oral and Maxillofacial Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran, E-mail:



Crown lengthening surgery is one of the most common periodontal surgeries. The analgesic effects of benzydamine and ibuprofen tablets have been proven in various studies. The purpose of this study was to compare benzydamine hydrochloride mouthwash 0.15% with ibuprofen in decreasing the pain of patients with crown lengthening surgery who had referred to the Periodontology Department of Yazd Dentistry School in 2015.

Materials & Methods:

In this clinical trial study, 36 patients aged 30 to 60 years who referred to the Periodontal Department of the Dental Faculty of Yazd University of Medical Sciences needing a crown lengthening surgery were randomly allocated to two groups. The patients of the first group were asked to wash their mouth using benzydamine hydrochloride mouthwash 0.15% after the surgery according to the instructed protocol and the patients in the second group were asked to take an ibuprofen tablet (400 mg) every 6 hours. After 24 hours, the level of pain was measured by using the numerical criteria of the Visual Analog Scale (VAS) and the data were analyzed using SPSS software version 18. T test and Mann-Whitney test were used as appropriate.


77.8% of the participants in the first group had mild pain and rest of the participants had moderate pain. 77.8% of the participants who used ibuprofen tablet reported mild pain, 16.7% had moderate pain and 5.6% had severe pain. The results did not illustrate more effect of ibuprofen on the reduction of pain after crown lengthening surgery compared with benzydamine hydrochloride 0.15% (P=0.48).


In the present study, there were no changes in the VAS index between the two groups. Therefore, in order to decrease pain after periodontal surgery, benzydamine hydrochloride mouthwash can be widely used as it has fewer side effects, lower price, and similar effects with ibuprofen.

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Keywords: Benzydamine hydrochloride, Crown lengthening, Ibuprofen, Mouthwash, Pain, Periodontal surgery.