RESEARCH ARTICLE


Evaluation of Effect of Surgical and Nonsurgical Periodontal Therapy on Serum C-Reactive Protein, Triglyceride, Cholesterol, Serum Lipoproteins and Fasting Blood Sugar in Patients with Severe Chronic Periodontitis



Amir Moeintaghavi1, Hamid Reza Arab2, Masoud Amiri Moghaddam2, Reza Shahmohammadi3, *, Bahareh Yalood Bardan4, Zahra Soroush4
1 Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Periodontology, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
3 Department of Endodontics, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
4 Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran


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Creative Commons License
© 2019 Moeintaghavi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Endodontics, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran; Tel: +989153115176; Fax: 9177948959; E-mail: drezashahm@gmail.com


Abstract

Background:

Cardiovascular disease has been associated with multiple risk factors such as dyslipidemia. However, the focus has recently shifted towards some novel risk factors i.e. infection from periodontitis.

Given this background, we aimed to assess the effect of periodontal therapy on some CVD risk factors including Total Cholesterol (TC), Low-Density Lipoprotein(LDL), High-Density Lipoprotein(HDL), Triglycerides(TG) and C-Reactive Protein (CRP). Fasting Blood Sugar (FBS) level has also been measured.

Methods:

Thirty patients (12 male and 18 female) who had severe periodontitis were tested for different blood parameters; namely Total Cholesterol (TC), Low-Density Lipoprotein (LDL), High-Density Lipoprotein(HDL), Triglycerides (TGs), C-Reactive Protein (CRP) and Fasting Blood Sugar (FBS). Enzymatic colorimetric methods were applied to measure all the parameters’ values except for CRP. The first stage of periodontal treatment comprised oral hygiene instruction as well as scaling and root planing. After 1 month, at the next stage, open flap debridement surgery was performed on all 4 quadrants of the mouth. The blood parameters were reassessed and compared with the baseline values after 3 months. Two patients (female) failed to participate in the follow-ups. The Pearson's and Spearman's correlation coefficients were calculated to determine whether changes in laboratory variables are associated with age and average probing depth or not.

Results:

All the assessed parameters related to 28 patients showed mean reduction which proved to be significant for CRP (p=0.011) and cholesterol (p=0.035). Among all parameters, only CRP level was found to have a significant positive correlation with pocket depth. Other blood parameters' relationship with age and probing depth proved to be insignificant.

Conclusion:

Considering the results, periodontal treatment may significantly lower lipid profile serum levels and some inflammatory factors.

Keywords: Dyslipidemia, Periodontitis, Cardiovascular diseases, Periodontal diseases, Immunoturbidimetry, Periodontal pocket.