RESEARCH ARTICLE


Effect of Herbal Echinacea on Recurrent Minor Oral Aphthous Ulcer



Faezeh Khozeimeh1, Zahra Saberi1, *, Atefeh Tavangar2, Fahime Fakhari Badi3
1 Dental Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, University Of Medical Sciences, Isfahan, Iran
2 Dental Material Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, Isfahan University Of Medical Sciences, Isfahan, Iran
3 School of Dentistry, Isfahan University Of Medical Sciences, Isfahan, Iran


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© 2018 Khozeimeh et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to the author at the Dental Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, Isfahan University Of Medical Sciences, Isfahan, Iran, Tel: +98-9133164817; E-mails: zahra.saberi@dnt.mui.ac.ir, saberi_777@yahoo.com


Abstract

Background:

The oral aphthous is a common oral ulcer with intense pain and there is no treatment for it, yet. Echinacea is an herbal medicine that moderated the immune system.

Objective:

The aim of this study was to investigate the effects of Echinacea on the treatment of aphthous ulcer.

Methods:

50 patients with minor aphthous participated in our study. 25 patients take 3 tablets in a day for five weeks (case group) and 25 patients didn’t take any tablets (control group). The patients were monitored for one month before taking the tablets for six months. During this period, the number of lesions, complete improvement of ulcers, recurrence rate and intensity of pain were considered in each month. Finally, the Friedman and ANOVA tests used to analyze the obtained data.

Result:

Our study showed a significant difference between a number of lesions during six-month in case and control groups (p>0.001). In this way, we observed that the number of lesions was decreased significantly after six months in the case group. Hence, ANOVA analysis showed a significant decrease between each month for the intensity of pain (p=0.025), complete improvement (p<0.001) and recurrence rate (p=0.026).

Conclusion:

In conclusion, we showed that Echinacea tablets as an herbal medicine have positive effects on a number of lesions, intensity of pain, complete improvement and recurrence rate in patients with recurrent minor aphthous ulcers.

Keywords: Minor oral aphthous, Herbal medicines, Echinacea, Oral mucosa problem, Herpetiformis ulcers, Water-soluble polysaccharides.