Perspectives of Immune Suppression in the Tumor Microenvironment Promoting Oral Malignancy
Nobuo Kondoh1, *, Masako Mizuno-Kamiya2, Eiji Takayama1, Harumi Kawati1, Naoki Umemura1, Yutaka Yamazaki3, Kenji Mitsudo4, Iwai Tohnai4
Identifiers and Pagination:Year: 2018
First Page: 455
Last Page: 465
Publisher ID: TODENTJ-12-455
Article History:Received Date: 13/04/2018
Revision Received Date: 15/05/2018
Acceptance Date: 29/05/2018
Electronic publication date: 20/6/2018
Collection year: 2018
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In order to survive, cancers control immune systems and evade immune detection using mediators consisting of immune checkpoint molecules and cellular systems associated with immune suppression.
During the development of cancer and chronic infections, the immune checkpoints and cellular components including regulatory T cells, myeloid derived suppressor cells and cancer associated fibroblasts are often enhanced as a mechanism of immune subversion and have therefore become very important therapeutic targets.
In this review, we will discuss the complexity of immune-suppressive mechanisms in the tumor milieu of cancers, including oral malignancy.