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Perspectives of Immune Suppression in the Tumor Microenvironment Promoting Oral Malignancy
Nobuo Kondoh1 , *
Masako Mizuno-Kamiya2
Eiji Takayama1
Harumi Kawati1
Naoki Umemura1
Yutaka Yamazaki3
Kenji Mitsudo4
Iwai Tohnai4
Authors Info & Affiliations
Masako Mizuno-Kamiya2
Eiji Takayama1
Harumi Kawati1
Naoki Umemura1
Yutaka Yamazaki3
Kenji Mitsudo4
Iwai Tohnai4
Authors Info & Affiliations
Abstract
Introduction:
In order to survive, cancers control immune systems and evade immune detection using mediators consisting of immune checkpoint molecules and cellular systems associated with immune suppression.
Methodology:
During the development of cancer and chronic infections, the immune checkpoints and cellular components including regulatory T cells, myeloid derived suppressor cells and cancer associated fibroblasts are often enhanced as a mechanism of immune subversion and have therefore become very important therapeutic targets.
Conclusion:
In this review, we will discuss the complexity of immune-suppressive mechanisms in the tumor milieu of cancers, including oral malignancy.
Keywords: Immune suppression, Tumor Microenvironment (TME), T-Regulatory cell (Treg), Myeloid Derived Suppressor Cell (MDSC), Cancer-Associated Fibroblasts (CAFs), Oral malignancy.
