CASE REPORT
Long-Term Effects of Acute Myeloid Leukemia Treatment on the Oral System in a Pediatric Patient
Saturnino Marco Lupi1, *, Arianna Rodriguez y Baena1, Gabriele Cervino2, Claudia Todaro1, Silvana Rizzo1
Article Information
Identifiers and Pagination:
Year: 2018Volume: 12
First Page: 230
Last Page: 237
Publisher ID: TODENTJ-12-230
DOI: 10.2174/1874210601812010230
Article History:
Received Date: 25/12/2017Revision Received Date: 20/02/2018
Acceptance Date: 28/02/2018
Electronic publication date: 30/03/2018
Collection year: 2018

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Introduction:
Acute Myeloid Leukemia (AML) in pediatric patients is a serious disease, although, for the subgroup of patients who receive proper treatment, a long-term survival rate above 50% is typical. The cycles of chemo- and radiotherapy used to treat AML can impair dental development.
Case Report:
Herein, we describe the oral condition of a 25-year-old male patient treated for AML with chemo- and radiotherapy from 5 to 7 years of age; his AML has remained in remission for the past 18 years. He had lost only one permanent tooth, but the remaining teeth demonstrated serious deformations and radicular hypoplasia. Two teeth required immediate extraction and subsequent replacement by implant-supported crowns. We found that the decayed, missing, filled teeth (DMFT) index was not representative of the real oral condition. Here, we report the full case and provide a brief review of the literature.
Conclusion:
Antitumor treatment of pediatric leukemia can induce total impairment of dental development and function. These adverse effects may become clinically evident many years after the resolution of cancer, and can be significantly detrimental to the patient’s quality of life.