A Review Over Benefits and Drawbacks of Combining Sodium Hypochlorite with Other Endodontic Materials

Zahed Mohammadi1, Sousan Shalavi2, Amir Moeintaghavi3, *, Hamid Jafarzadeh4
1 Iranian Center for Endodontic Research (ICER), Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Private Dental Practice, Hamedan, Iran
3 Department of Periodontics, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
4 Department of Endodontics, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran

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© 2017 Mohammadi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Periodontics and Endodontics, Mashhad University of Medical Sciences, Iran, P.O. Box: 91735-984, Iran; Tel: +98-51-38829501; Fax: +98-51-38829500; E-mails:;



As the root canal system considered to be complex and unpredictable, using root canal irrigants and medicaments are essential in order to enhance the disinfection of the canal. Sodium hypochlorite is the most common irrigant in endodontics. Despite its excellent antimicrobial activity and tissue solubility, sodium hypochlorite lacks some important properties such as substantivity and smear layer removing ability.


The aim of this review was to address benefits and drawbacks of combining sodium hypochlorite with other root canal irrigants and medicaments.


According to the reviewed articles, NaOCl is the most common irrigation solution in endodontics. However, it has some drawbacks such as inability to remove smear layer. One of the drawbacks of NaOCl is its inability to remove the smear layer and lack of substantivity.


The adjunctive use of other materials has been suggested to improve NaOCl efficacy. Nevertheless, further studies are required in this field.

Keywords: Sodium hypochlorite, Interaction, Root canal irrigation, Smear layer, Antimicrobial activity, Medicaments.