Ozone Treatment on Dentin Hypersensitivity Surfaces – A Pilot Study

Karlsson Lena*, Kjaeldgaard Marianne
Department of Dental Medicine, Cariology and Endodontology, Karolinska Institutet, Sweden

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Creative Commons License
© Lena and Marianne; Licensee Bentham Open

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Dental Medicine, Karolinska Institutet, Box 4064, SE-141 04 Huddinge, Sweden; Tel: +46 8 52488257; E-mail:



Dentin hypersensitivity (DH) is a frequent condition in adults and difficult to treat. The aim of this single-blind, randomised controlled clinical trial was to investigate immediate and long-term effect of ozone treatment (Prozone, W&H NORDIC AB) for 12 seconds on hypersensitive teeth compared to placebo treatment, using a split-mouth design.


26 patients (12 M, 14 F, mean age 44+ 2) were included in the study having at least two teeth with confirmed DH in different quadrants of the dentition (each subject had one test and one control tooth). A visual analogue scale (VAS) was used to measure the patients´ pain perception immediately and at a long-term follow-up three months later.


Significant reduction in pain perception from DH surfaces was demonstrated from ozone treated test teeth as well as in placebo treated control teeth. We found a moderate (16.2%) but significant pain relief (p< 0.012) over time in 57.7% of all treated teeth.


Results from this study confirm previously published results showing no significant effect of ozone treatment on hypersensitive teeth compared to placebo treatment.

Keywords: Dentin Hypersensitivity, Randomised Clinical Trial, Ozone, Placebo Treatment, Split-mouth Design.