RESEARCH ARTICLE


The Effect of Scaling and Root Planning on Salivary TNF-α and IL-1α Concentrations in Patients with Chronic Periodontitis



Masoome Eivazi1, Negar Falahi2, Nastaran Eivazi3, Mohammad Ali Eivazi4, Asad Vaisi Raygani5, Fatemeh Rezaei6, *
1 Department of Periodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
3 Department of ENT, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
4 Department of Pharmacoeconomics and Pharmaceutical Management, School of Pharmacy, Shahid Beheshti University of Medical Sciences,Tehran, Iran
5 Department of Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
6 Department of Oral Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran


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© 2017 Eivazi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Oral Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran; Tel: 98-918-8371081; E-mail: f.rezaei@kums.ac.ir


Abstract

Objective:

Periodontitis is one of the main diseases in the oral cavity that causes tooth loss. The host immune response and inflammatory factors have important role in periodontal tissue. The current study was done with the objective to determine the effect of scaling and root planning on the salivary concentrations of tumor necrosis factor-alpha (TNF-α) and interleukin-1-alpha (IL-1α).

Methods:

In this quasi-experimental clinical trial, 29 patients with chronic periodontitis and 29 healthy subjects without periodontitis were studied. Clinical examination findings and salivary TNF-α and IL-1α (using ELISA method) were compared before and after scaling, root planning.

Results:

Before starting treatment, salivary TNF-α and IL-1α concentrations were higher in healthy control group than in periodontitis group (P< 0.05). Non-surgical treatment increased the concentration of these two biomarkers in the saliva. However, increase in IL-1α concentration was not statistically significant (P= 0.056). There was a negative relationship between TNF-α and IL-1α levels with pocket depth and attachment loss (P< 0.05).

Conclusion:

Scaling and root planning improved periodontal disease indices and salivary TNF-α and IL-1α levels.

Keywords: Chronic periodontitis, Non-surgical treatment, Saliva, TNF-α, IL-1α, ELISA method.