OHRQoL in a Sample of Alcohol and Drug Abusers

INTRODUCTION

In medicine, mortality and morbidity no longer are the only important outcomes of prevention, cure and care. In the last decades, attention to patient-reported outcomes measures (PROM’s) such as health-related quality of life, has been growing rapidly [1]. This is an acknowledgement of the fact that broader measures are needed, in order to incorporate the patients perspective on his health, impairments and disabilities. Also in dentistry nowadays, many instruments are available to measure oral health-related quality of life [2, 3]. One of the most commonly used instruments to measure oral health-related quality of life is the Oral Health Impact Profile (OHIP-49) or its short form alternative (OHIP-14). The OHIP-49 [4] is based on seven dimensions derived from Locker’s conceptual model of oral health [5]. An hierarchical ordering exists among these seven dimensions which implies that the impact described by each subsequent dimension is considered to be gradually more disruptive to one’s life [6].

The concept of quality of life is intuitively appealing. That is, most people seem to have a sense of what it should mean, comparable for instance to a concept as intelligence. As a result, quality of life has found its way into several different fields of science such as sociology, medicine, nursing, psychology, economics, geography, social history and philosophy [7]. Unfortunately, this has led to multiple definitions and meanings and therefore little consensus seems to exist on its definition and how to measure it [1], making it primarily a generic concept. In addition, quality of life is a dynamic concept [8]. It reflects a subjective evaluation or appreciation of the degree to which someone is satisfied with life in general. This subjective evaluation is not necessarily consistent and the factors determining one's quality of life may differ within a person (compare for instance young and old people), but also between people (what seems important for one person may be irrelevant for another). Health in general, and also oral health, can be considered as universal factors that might have a profound influence on quality of life for most people. One special group in modern society is one in which general health, oral health, psychological wellbeing and thus quality of life are seriously deteriorated, are alcohol and drug abusers.

Patients referred to a dental care clinic (in the Netherlands) specialized in treating substance abusers can be considered to be severely addicted. One study [9] showed that about 83% of patients reported having used heroin, 83% cocaine, amphetamine (23%) and hallucinogens (16%). About 90% of patients were poly-drug abusers and 46% of them were injecting drug users. From the patients that inject drugs, 90% had Hepatitis B, 90% had Hepatitis C, 30% were HIV positive and 13% had endocarditis. A single alcohol addiction was present in only 10% of patients. In addition to the aforementioned severity, the duration of the addiction is typically 8 years or more. Besides their addiction and associated general health problems, these patients also typically have an impaired psychological wellbeing [10]. Nearly all patients suffer from some sort of psychopathology. About 95% has at least one type of disorder according to the criteria of the DSM-IV. In addition, research has shown that such patients report, on average, much higher levels of dental anxiety than the general population [11]. Drug abuse also has a strong impact on oral health [12]. One study has shown that substance abusers have higher DMFS scores than the general population, resulting from more active caries in fewer elements and less restorations [13, 14]. In addition, it is important to realize that psychotropic substances often leads to a reduced saliva production, thereby undermining the mouth’s natural defense mechanism [15, 16], resulting in an increased risk of developing caries. The large number of carious dental elements, in combination with the lack of regular oral health care, often leads to a severely mutilated dentition. The use of stimulants such as alcohol and cocaine can cause extensive bruxism resulting in attrition of the teeth [12-17]. Attrition in combination with impaired function due to missing elements may to lead to temporomandibular dysfunction [18].

In short, pain as a result of active caries, fear of dental treatment, psychopathological disorders, and impaired aesthetic due to the lack of teeth, especially at the upper front, can clearly lead to a reduced quality of life. To our best knowledge, no studies exist that have examined OHRQoL in substance abusers. Therefore, the aim of this study was [1] to evaluate determine OHRQoL in a large sample of substance abusers, and [2] to investigate the effect of dental treatment, at a center for specialized dental care, on OHRQoL.

MATERIAL AND METHODS

RESULTS

Baseline Measurement T0

Mean OHIP-14 total- and subscale scores were calculated, and are presented in Table 1 (column T0). ANOVA for repeated measures showed a significant difference between subscale scores, F (6, 104) = 28.98, p < 0.001. Subsequent analysis shows that the lowest mean score is reported for the subscale functional limitation (p < 0.015 relative to all other subscale scores). A significant higher mean score is noted for the subscales physical disability, social disability and handicap (p < 0.001). The highest scores are reported on the subscales physical pain, psychological discomfort and psychological disability (p < 0.02).

Table 1.

	T0 (N=110)	T1 (N=392)	T2 (N=136)	T3 (N=81)
	Mean	SD	Mean	SD	Mean	SD	Mean	SD
OHIP total	40.6	12.9	37.1	12.4	31.9	10.8	29.5	10.0
1. Functional limitation	4.7 1	2.3	4.1 1	2.0	4.0 1	2.0	4.2 2	1.8
2. Physical pain	6.6 3	2.0	6.5 4	2.1	5.5 4	1.9	5.2 3	1.9
3. Psychological discomfort	6.9 3	2.5	6.3 4	2.3	5.6 4	2.2	4.8 3	2.0
4. Physical disability	5.5 2	2.3	4.9 2	2.2	4.4 2	2.0	4.0 2	1.9
5. Psychological disability	6.4 3	2.2	5.6 3	2.3	4.8 3	2.0	4.2 2	1.7
6. Social disability	5.3 2	2.3	4.9 2	2.2	3.9 1	1.9	3.6 1	1.6
7. Handicap	5.4 2	2.1	4.8 2	2.1	3.9 1	1.8	3.5 1	1.7

¹ = lowest score, significantly different from each higher number.
^2,3,4 = in the same column, scores with the same number do not differ significantly from each other.

In order to test for a (natural) change in OHRQoL scores between T0 (waiting list) and T1 (first day at the clinic), paired samples t-tests were performed on total- and subscale scores. A strong association exists between scores at T0 and T1 (lowest correlation r = 0.61, N = 44, p < 0.001), but no significant differences on total- or subscale scores (range p-values = 0.26 – 0.72). One exception is the subscale physical disability, where a marginally yet non-significant decrease in mean score was found, mean difference = -0.45 (s.d. = 1.74), t (43) = 1.71, p = 0.095.

In order to assess whether a difference exists between participants that filled out the questionnaire at T0, and those that did not, mean scores at 1 between the two groups were compared using independent-samples t-tests. For 44 out of 110 participants, a score at T0 and T1 was available. Their mean score was compared to all other scores available at T1 (N = 348). No significant differences were found on the total- or subscale scores between the two groups. Only for the subscale functional limitation a difference was found (p = 0.021), resulting from a higher mean score from the group

that did respond on T0 (mean difference 0.73), but this became non-significant after correcting for unequal variances (significant Levene test), t (50.02) = 1.93 p = 0.059. Non-parametric analysis confirmed this conclusion (Mann-Whitney U), Z = -1.785, p = 0.074.

DISCUSSION

In the present study, OHRQoL was examined in a large sample of substance abusers using the OHIP-14. Data from 392 patients was available at T1. Results show that the impact of oral health on these patients (mean OHIP-14 score = 37.1, s.d. = 12.4) can be considered to be substantial. That is, it appears substantial if the mean scores found in the present study are compared to those found in other studies using different samples. For instance, in a study concerning the impact of third molar surgery on OHRQoL in the first postoperative week a mean OHIP-14 total score of 34.3 was found [21]. This suggests that the sample in the present study reports to experience more impact of oral health on quality of life (at T1) than patients that have just undergone third molar extraction surgery. Also patients suffering from a dentofacial deformity that requires orthognathic surgery score lower (mean = 34.97) than the present sample [22]. The same is true for patients with general periodontal problems and severe periodontitis [23]. Please note that one needs to be very careful with comparisons as given here [8] since each patient sample is characterized by its own specific problems. A generic instrument such as the OHIP-14 may not fully capture the impact of such specific problems, thereby preventing a valid comparison. As formulated by other authors “No single instrument can be regarded as a standard, comprehensive instrument for measurement of OHRQoL” [3]. However, it does give the reader a general impression of the impact of oral health on the current sample. For instance, the mean OHIP-14 score for the general Dutch population is 16.8 [20] which is substantially lower than found in the present sample.

Despite the fact that only a limited number of treatment sessions took place (6 on average), dental treatment (between T1 and T2) resulted in a significant reduction in mean OHIP-14 total- and subscale scores. It is clear that treatment at the dental care clinic specialized in substance abusers had beneficial effects for patients in terms of improved oral health related quality of life. The authors believe that the Molendijk treatment model plays a crucial role in this beneficial effect. A significant reduction in mean OHIP-14 total- and subscale scores was also found when comparing T2 with T3, albeit much less than expected (31.95 vs 29.54). Several explanations can be given for this relatively modest improvement. One important explanation relates to the fact that many patients did not complete the study. It appears, and was anticipated in advance, that patients who improved substantially (for instance pain free, restored upper front teeth, partial prosthesis etc) quite often did not return to complete treatment. In other words, when patients are relieved from their most serious problems, they will also experience a reduced need to comply with treatment. Another related explanation is that a part of the patients did not return for a long time, but when they did return it was because of newly acquired dental problems. For instance, alcohol abusers and drug abusers in general, who experience withdrawal issues, often fall and break parts of their dentition, and return to the clinic with increased OHIP-14 scores relative to when they left. Other examples are patients that had their (partial) denture repaired, had to go to jail for one year, and returned with a broken denture. One final explanation is related to the Molendijk treatment model. Since it is known that substance abusers have a tendency not to comply with treatment after their largest dental problems have been solved, one rule of the Molendijk model is to wait (when possible) with placing of (partial) dentures until the final day of treatment. As a result, a part of the patients only received their denture at T3. As such, their score does not reflect the benefits of their new dentures, but is based on a (partly) edentulous mouth.

One important limitation to the present study is the high dropout rate of patients. A total sample of 392 patients participated at T1, and only 81 remained at T3. However, this was anticipated and the main reason for including as much patients as possible given the time frame for the study. For instance, during the study period 11 patients deceased. However, as reasoned above, the authors believe that dropout is primarily related to a substantially improved OHRQoL which often results in decreased compliance with therapy. Therefore, the authors feel that the results presented for T2 and T3 are likely to give an underestimation of the effect of dental treatment on these patients. It may be clear that the present population is hard to reach and follow, in particular with a longitudinal study design. The fact that only patients referred to one special dental care clinic in Amsterdam participated does not necessarily limit the generalisability of the results, since patients are referred to this clinic from all over the country. However, it does concern a sample of severely addicted patients (i.e. using drugs for a long time) with psychopathological problems (most were referred by a psychiatrist from the abuse treatment center). The question whether these results apply to substance abusers in other countries remains to be seen. The Netherlands is a country with a highly developed social system providing support for the weakest in society. In other words, a large part of the substance abusers in the Netherlands has a house, a smaller part has work, and all have access to dental care and health care. In countries where the social system is less developed, substance abusers may be more likely to be without a job, live on the streets more often and have no or limited access to dental and general health care. One additional limitation is that in the current study no standardized measures of oral health status were obtained (i.e. DMFT, caries index, periodontal index, tooth mobility etc.) as was done in other studies [24]. In future studies, such information should be considered as it gives a more differentiated picture and will allow for specific subsample analyses.

To conclude, the results from the present study show that dental treatment has a substantial positive effect on OHRQoL as measured using the OHIP-14. An important result given the observation that general practitioners would treat an addicted patient differently from a non-addicted patient [19]. That is, for an addicted patient the general practitioner would more often extract a teeth than fill it, and would more often propose to use fillings and partial dentures rather than using crowns and bridges. However, results from the present study show that addicted patients can benefit to a great extent from ‘conventional’ dental treatment when following a treatment model specifically tailored to addicted patients. Moreover, it is important to realize that psycho-active drugs mask bodily pain signals. It is the moment of withdrawal that the addicted patient has the severest dental pain. Therefore, it is advisable to plan dental treatment, if possible, just before or in the beginning of the withdrawal or therapy. Dental treatment should be integrated in addiction programs to reduce drug-related harm and to optimize re-socialization of the addicted patient.

CONFLICT OF INTEREST

The authors confirm that this article content has no conflict of interest.

REFERENCES