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RESEARCH ARTICLE

Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients

Kosuke Naganawa 1 , 2 Eiji Takayama 1 Makoto Adachi 2 , 3 Kenji Mitsudo 3 Masaki Iida 3 Masako Kamiya-Mizuno 1 Harumi Kawaki 1 Masao Ichinose 4 Masayuki Motohashi 2 Yasunori Muramatsu 2 Iwai Tohnai 3 Shin-Ichiro Sumitomo 2 Michio Shikimori 2 Nobuo Kondoh 1 , * Open Modal Authors Info & Affiliations
The Open Dentistry Journal • 31 Mar 2015 • RESEARCH ARTICLE • DOI: 10.2174/1874210601509010120

Abstract

In order to evaluate the Th1 and Th2 responses of Oral Squamous Cell Carcinoma (OSCC) patients, we investigated the cytokine producing capability of peripheral blood (PB), and compared it with clinicopathological appearances of OSCC patients. The production of a Th1-type cytokine, interferon (IFN)-γ, from lipopolysaccharide (LPS)-stimulated PB correlated positively with the frequency of lymph node metastasis. We also investigated the production of a Th2-type cytokine, IL-10, however, no significant correlation was observed with the clinicopathological appearances. Our results suggested that the IFN-γ producing capability was specifically regulated and dependent on the regional metastatic potencies of OSCCs.

Keywords: Cytokine-producing capability, interferon-gamma (IFN-γ), Oral squamous cell carcinoma, peripheral blood, tumor immunology.
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