When restoring a tooth, the clinician faces the dilemma: Which material should he use? . The major factors that may influence the final choice are esthetics and strength of the prostheses.
Metal ceramic fixed partial dentures (FPDs) are considered the gold standard, as reliable materials. However, the request for esthetic dentistry as well as the rising question regarding biocompatibility of dental alloys, support the commercialization of new products . Nowadays, all-ceramic prostheses are replacing, more and more, metal-based restorations . A variety of ceramic systems are developed for single crowns or fixed dental prostheses (FDPs) with an excellent esthetic outcome .
Traditional ceramics (glass- glass-reinforced, and feldspathic ceramics) and also Al2O3-reinforced ceramics encountered some problems, especially in the molar region . Ceramic material used, core-veneered bond-strength, and crown thickness are some factors essential to withstand occlusal forces . The reliability of industrially prefabricated ceramics block appears to be more consistent than laboratory manually processed ceramics [6, 7].
Transformation-toughened zirconia is prone to be a successful alternative in the different clinical situations compared to other all-ceramic systems . Their mechanical and optical properties allowed them to be used as a framework material. In vitro studies demonstrated a flexural strength of 900–1200MPa [9, 10], and a fracture toughness of 9–10MP am 1/2 [2, 11]. The restorations are processed either by soft machining of presintered blanks followed by sintering at high temperature, or by hard machining of fully sintered blanks [12, 13].
This review article describes the current status of zirconia-based fixed restorations, including results of current in vitro studies and the clinical performance of these restorations .
Since its development in 2001 , direct ceramic soft- machining of pre-sintered 3Y-TZP is now on the market. First, the die or the wax pattern is scanned, the computer software (CAD) designs an enlarged restoration and computer aided machining mill a pre-sintered ceramic blank. The restoration is then sintered at high temperature .
Hard-machining Y-TZP blanks consist of milling restorations in very high density blocks, presintered at 99% of the theoretical density . The milling system has to be particularly robust due to the high hardness and low machinability of fully sintered Y-TZP .
Same 5-years survival rates have been reported for all-ceramic crowns and metal-ceramic for anterior teeth. When utilized for premolars and molars the success decreased to 90.4% and 84.4% respectively for In: ceram crowns and glass–ceramic crowns [15-17]. The force, contact area and duration were greater for molar chewing cycles than incisor ones . The most common complication encountered with all-ceramic crowns was crown fracture .
Up to 3-years published controlled clinical studies of zirconia-based crowns reported lower complication rates [20, 21]. The authors concluded that Y-TZP could sufficiently withstand functional load in the posterior zone . However, as mentioned by Conrad and others, following traditional preparation guidelines will better distribute stress during dynamic loading of the restoration [5, 23].
An electronic search has been conducted, during July 2013, via PubMed and Elsevier. Peer-reviewed articles were targeted. The following key-words have been used: Zirconia, zirconia restorations, allceram, zirconia crowns, zirconia FPDs, zirconia bonding, and zirconia strength. Available full-text articles were read. Related articles were also scrutinized. No hand search was driven.
The mechanical properties of zirconia allowed them to be used in posterior FPDs and permit substantial reduction in core thickness .
Under ambient pressure, the temperature will influence the crystallographic form of unalloyed zirconia. At room temperature and upon heating up to 1170 °C, the structure is monoclinic. Then it is tetragonal between 1170 and 2370 °C and cubic above 2370 °C and up to the melting point . Upon cooling, transformation from the tetragonal (t) phase to the monoclinic (m) phase will induce a substantial increase in volume (~4.5%). This will lead to catastrophic failure. Adding CaO, MgO, Y2O3 or CeO2 to zirconia-alloys allows the retention of the tetragonal structure at room temperature. This will control the stress-inducing t→m transformation. Compressive stresses developed in the vicinity of a crack tip, arrest crack propagation and lead to high toughness [13, 25, 26].
Composition, grain size, shape of the zirconia particles, type and amount of the stabilizing oxides, interaction of zirconia with other phases and processing are also factors that have impact on the metastability of the transformation .
However, grinding or sandblasting are responsible to cause the t→m transformation altering the phase integrity of the material and increasing the susceptibility to aging [27, 28]. The presence of water will exacerbate this well-documented "Low Temperature Degradation" (LTD) [29, 30]. The Y2O3 can react with the aqueous environment producing yttrium hydroxide (Y[OH]3H2O) [31, 27]. Grain pullout and microcracking as well as decrease in strength are reported consequences of this aging process [13, 32]. Frameworks or parts of a framework that are not veneered as well as zirconia implants and abutments exposed to the oral environment, are subjected to this phenomenon. This is why during framework design, non-veneered zirconia should be avoided .
Innovative bioceramics such as zirconia magnesia (Mg-PSZ with bioactive glass coating)  and alumina composites TZP stabilized  are recently reported as degradation-free materials .
Both in vitro and in vivo studies demonstrated that fracture of the connectors was the exclusive mode of failure in all-ceramic FPDs [36, 37]. Connector fracture was initiated at the gingival embrasure. Concentration of tensile stresses can be reduced by larger radius of curvature at the gingival embrasure . Whereas, sharp occlusal embrasures did not affect FPDs' fracture resistance [39, 40].
An occlusogingival height of 2.5 mm and a buccolingual width of 2.5 mm of the connectors (a connector surface area of 6.25 mm2) are sufficient to ensure long-term success of metal-ceramic FPDs . These dimensions are achievable both in the anterior and in the posterior segments.
Mechanical strength of zirconia frameworks is up to three-times higher than other allceram. It can withstand physiological occlusal forces applied in the posterior region [4, 14, 42, 43] Even rare, framework fractures in all-ceram FPDs were reported in the connector region [4, 44-46]. Therefore, connector dimensions are crucial for fracture resistance .
Fracture propagated from the gingival surface of the connector toward the pontic . A connector dimension of 3×3 mm increased the fracture strength of zirconia-based FPDs by 20% [44, 48, 49]. Required dimensions for the connector could still be smaller than for other all-ceramic core materials . Even though, some authors recommended a connector dimension of 4×4 mm and that the framework must support the veneering porcelain, which should not include more than 2.0 mm of unsupported veneering material [14, 27, 50-52]. Worth noting that bulk fracture appears to be quite uncommon .
The major problem encountered is porcelain cracking. The difficulties are material-specific with an incidence from 8 to 50% [53, 54]. Thickness ratios or framework design also play a role. For comparison, porcelain problems on metal–ceramic prosthesis over a 10 years observation period was reported to be, no higher than 6% for most alternative alloys, . 98% completely intact porcelain at 5 years was reported for goldbased alloy [56, 69]. Thus, porcelain–zirconia compatibility is to be considered .
Zirconia–porcelain interface may be involved in crazing and chipping during function. Stresses could be related to surface property, as bulk thermal expansion/contraction mismatches does not appear to be the cause . The aggressivity of silicate glasses as solvents of refractory materials at high temperature is known . Under firing conditions, aluminum oxide is soluble in dental porcelains . Cerium and zirconium diffuse into a glass used to infiltrate a partially sintered Ce-TZP powder . Lessening of stabilizing dopants (e.g., Y and Ce) might induce local changes in zirconia surface  resulting in destabilization of the t-phase  with quite high local associated strains . Liquid silicate can penetrate the grain boundaries perhaps analogous to water penetration of Y-TZP [13, 63].
CHIPPING AND FAILURES
Chipping is defined as "a typical failure of contact loadings, normally produced when a crack generated or propagated by contact loads deflects due to the presence of a free surface nearby" [64, 65]. Tensile stress induces fracture of the brittle ceramic usually perpendicular to the applied force .
Thermal coefficient mismatches, processing (porosity, impurity inclusion) and inherent material defects (large grains, residual scratches) will increase the probability of crack propagation under loading . Brittle fracture of ceramics will be triggered adjacent to these zones .
In the case of metal-ceramic prostheses, an adherent layer of oxide is essential to achieve a strong bond. This will enhance the wettability and the adherence of the ceramic. When the temperature attains a certain level, part of this oxide will be dissolved into the glass. In the case of nickel-chromium alloys, excess oxide production will cause weak bonding . High-gold alloys will produce an adequate oxide layer for a solid bond with the porcelain .
The zirconia core–veneer bond should also be strong enough to gain profit from exceptional properties of the framework. However, according to Aboushelib, this bond strength is lower than for other all-ceram systems . This can induce chipping and delamination under friction. Framework surface treatment, the surface finish, the type and method of application of the veneer ceramic will affect this bonding .
If no fractures of the zirconia framework have been reported , chip-off fracture rates up to 20% was observed at 5-years follow-up period [4, 5]. In the case of metal framework FPDs, a review of the literature revealed either no fracture of the veneering ceramic  or substantially lower fracture rates ranging from 2.7% up to 5.5% for observation periods from 10 to 15 years [2, 72, 73].
Adequate framework design, proper veneering ceramic support and thickness are factors implicated in the ceramic survival . Moreover, occlusal forces, such as direction, magnitude and frequency are to be taken into consideration [2, 75]. Roughness of the veneer that results from occlusal contacts or grinding may induct chipping. Fractography analysis revealed that crack propagation originated from wear area and occlusal adjustments [27, 76, 77]. Studies have shown that sandblasting and sharp indentations even at very low loads are very harmful to long-term longevity of zirconia [78-80].
Marchack et al. demonstrated that scanning of full contour waxing will provide an optimal porcelain thickness on appropriate coping design . This will decrease porcelain fracture [14, 82]. It has been recommended that the veneer thickness does not exceed two-fold of the core thickness. The pontic framework must have an anatomical shape to support veneers' cusps . However, a completely suitable veneer system has not yet been found. Differences in microtensile bond strength between several veneering porcelains have been shown . Strong veneering systems are recommended to avoid chipping .
For others, the thermal expansion coefficient (TEC) plays a major role far before the zirconia-veneer bond strength [85, 86, 77]. Most manufacturers provide veneering porcelains having a slight mismatch between their porcelain and zirconia, with the porcelain having approximately TEC lower than the zirconia TEC . Desirable residual compressive stress in the veneering ceramic is present when a framework material with a slightly higher TEC is used . In contrast, when Zirconia's TEC is lower than ceramic's, veneer delamination and microcracks occurred [69, 88]. This approach is used for most metal-ceramic systems and non-zirconia all-ceramic systems [89, 90, 13]. Therefore, if a compatibility issue is occurring with Y-TZP, it is likely not only due to a simple thermal expansion coefficient mismatch between the bulk materials . Low fusing veneering ceramics with similar TEC have been developed. Grain size may also play a role . The wide range of sintering temperature has an incidence on the particle size and later on the phase stability of zirconia-yittria .
Some recent studies described a layering method of indirect composite onto a zirconia framework [61-66]. A short term in-vitro study reported a superior bond strength by using a priming agent containing the functional monomer MDP . Plastic and viscoelastic effects, as well as susceptibility to creep And recovery [67, 68] are advantageous properties of using composite, especially in areas of high occlusal stress [69, 87].
Zirconia presents a thermoconductivity much lower than that of other framework materials [6, 9]. This low thermal conductivity retards the ceramic cooling rate at the interface. This generates thermal residual stress [91, 92]. It may induce thermal cycling delamination of the veneering porcelain . The effect of different cooling rates (rapid and slow) on the bond strength between layering porcelain and zirconia ceramics has been assessed [93, 94]. Prolonged cooling phases have been proposed to reduce this stress and veneer chipping [83, 95, 96]. Slow cooling time ameliorated the resistance of the veneered zirconia restorations [76, 97], and enhanced the shear bond strength . However, Gostemeyer et al. argued that adding 5 min cooling in the furnace lowered the bond strength . Komine noticed that these conflicting findings are the result of different cooling and testing methods .
Applying a liner material has been proposed to mask the opacity of the zirconia-core. Unfortunately, this reduced the core-veneer bond-strength and increased the percentage of interfacial failure [70, 84]. Kim and Fischer agreed on the negative effect of liner application [86, 98, 99]. Aboushelid contraindicated their use with Press-on ceramics . The lower strength of liners compared to dentine ceramic may play a role in these negative results. Still, others found that liner materials enhances the bond strength between zirconia and some layering ceramic .
LAYERED /PRESSED VENEERING CERAMICS
Cohesive and adhesive failures of the veneering are recurrent complications of veneered zirconia frameworks .
To counteract this tendency, the "overpressing technique" has been proposed. A specific ceramic is pressed onto the zirconia framework . According to Beuer et al.  this technique is reliable since no chipping has been detected .
Fabrication of conventional dental porcelains consists of a frit condensation followed by a sintering process. Sintering may introduce thermally induced residual stresses . This can modify the measured biaxial flexure strength [103-105]. The moisture content of the veneering material during sintering might induce changes in the zirconia/veneering interface and provoke transformation from the tetragonal phase to the monoclinic phase . Swain et al.  preconized that residual stresses and contact-induced cracking will develop chip-fracture. Beuer et al.  reported higher strength of CAD/CAM veneering ceramic compared to the layered veneering technique. Using of the pressed ceramic may reduce the chipping incidence , since the heatpressing fabrication method would reduce the formation of large flaws and minimize the thermally induces residual stresses [102, 105]. The manufactured blanks are reported flawless. Greater porosities are entrapped during fabrication stages in dental laboratory, added to human errors [107, 108]. The shrinkage level of the porcelain may be related to the ratio of the mixed powder/liquid veneering ceramic. Minimal three firing cycles are needed. Catastrophic failures can be induced by the incorporation of small impurities like inhomogenities, pores, since cracks cannot be healed but slow growth may occur under oral conditions [108, 109]. The pressing technique permit the creation of desired tooth anatomy while minimizing firing shrinkage .
The manufactured CAD/CAM veneer will be joined to the zirconia framework by fusion glass ceramic or by using resin cement . Lithium disilicate has been proposed to be connected to zirconia framework by glass fusion ceramic [76, 112]. Higher tensile strength of press-on veneers and the superior quality of the interface can prevent porcelain chipping . These materials exhibited better fracture strength and fatigue behavior when compared to the hand-layered ceramics. The latter show early veneer failures under mouth-motion cyclic loading [76, 113].
In one recent study, overpressed zirconia three-unit posterior prostheses had significantly less fractures and chippings compared with layered ones . In another study no chipping was observed [101, 108]. Ishibe and Aboushelid recommended the application of press-on veneer ceramics directly onto air-borne-particle-abraded surfaces [70, 84, 115, 116]. However, other studies found no difference in fracture incidence between the pressed and layered techniques [100, 108, 117].
Connector design had an incidence on milled ceramic fracture resistance, but not the pressed ceramic .
SHEAR BOND STRENGTH AND INFLUENCE OF ARTIFICIAL AGEING
In metal-ceramic prostheses, as determined by the International Standards Organization (ISO) , the minimum required bond strength between metal and layering porcelain is 25 MPa. No such estimate has been yet determined for all-ceram . Comparison between zirconia- and metal-ceramic restorations found a similar bond strength [88, 115, 120, 121]. Other studies reported greater bond strength between porcelain and zirconia than for metal-zirconia [2, 122]. Results are conflicting .
Guess found metal-ceramic shear bond strength (SBS) higher than zirconia-ceramic one's. Thermocycling has no effect on zirconia-ceramic bond . Yet, Silva noticed that in contrast to Y-TZP systems where failures were accelerated by fatigue, metal-ceramic restorations failures occurred as a function of load and not fatigue .
The difference in the results between metal- and zirconia-ceramic SBS could be reported to the dissimilar adhesion mechanisms. If mechanical interlocking and chemical bond resulting from suitable metal oxidation and interdiffusion of ions are essential in the metal ceramic interface, the Y-TZP-ceramic bonding mechanisms are still unclear [124, 125]. For the latter, some micromechanical interactions can just be assumed based on the wettability of zirconia-core by veneering ceramic .
When Ishibe and Aboushelib compared zirconia-layered ceramic shear bond strength to zirconia-pressed one, they found equivalent results [70, 84, 115].
Oral fluids are known to facilitate stress corrosion of ceramic materials. Water molecule will diffuse into the glass and provoke a corrosion mechanism . Dissolution of ceramic can happen through 2 ways: by ionic exchange during exposure to an acidic solution, or by breakdown of Si-O network in a basic solution . The intensity of chemical deterioration is related to the glass matrix composition and the ratio of crystal incorporation . This will result in slow crack growth and may lead to failure of ceramic restorations in the oral cavity complex situation [2, 128, 129]. So some concerns are assessed regarding zirconium dioxide structural stability when it's exposed to oral environment [6, 27] .
Different zirconia systems were tested in vitro, using artificial aging, through dynamic loading and thermal cycling. No significant effects on the fracture load were observed for 3-unit FDPs, and no failures occurred [4, 130, 131]. Thermocycling had no incidence on the zirconia-layered-ceramic bond [2, 88]. The bond strength stability is equivalent to results found about bonding of porcelain-metal framework [87, 88, 132].
Schmitter noticed that artificial aging has no incidence on CAD/CAM ceramics, in contrast with the manually veneered crowns . Another study found no difference between the two veneering methods after aging . No difference in the fatigue properties of the Zirconia Everest® core material following sintering or heat pressing of the veneering material was detected .
Analyses of the fracture surfaces for the pressed ceramic, revealed a combined adhesive and cohesive failure scheme independent of the ageing . Even on polished zirconia, the failure was mostly cohesive within the veneering ceramic [69, 86]. The flexure strength varied between 70 and 100 MPa, depending of the product [108, 134]. The flexural strength of the zirconia veneering porcelain, similar to metal-ceramics, will block the propagation of the crack due to the tetragonal phase [69, 108].
Stawarczyk concluded that overpressed veneering porcelains for zirconia single crown frameworks exhibited similar or better fracture load compared with layered ones . Guess noticed that hand-layer-veneered zirconia crowns revealed a high susceptibility to mouth-motion cyclic loading in early veneer failures . Other factors such as grain size and shape and porosity should also be considered . Grain size strongly affect the mechanical properties of 3Y-TZP [14, 20, 21]. On the other hand, sintering temperatures will influence the grain size and the phase stability of 3Y-TZP .
Soft machining restorations are sintered at a later stage. This will prevent the stress-induced transformation from tetragonal to monoclinic. The final surface will virtually be free of monoclinic phase unless grinding adjustments are needed or sandblasting is performed . In contrast, hardmachined restorations of fully sintered 3Y-TZP blocks contain a significant amount of monoclinic zirconia . This may result in surface microcracking, higher susceptibility to LTD and lower reliability .
Several searches studied the fatigue behavior of 3Y-TZP [28-31]. When tested in cyclic loading, both sandblasting and sharp indentations even at very low loads are harmful to the long-term performance of 3Y-TZP [13, 29-31]. The presence of residual stresses was detrimental in promoting LTD .
Worth to be noticed that the pressable ceramic materials showed significantly less change in marginal opening than metal ceramic and copy milled ceramic crowns .
COLOR AND ESTHETICS
Tooth Enamel, constituted of 97% hydroxyapatite mineral, is very translucent and can transmit up to 70% of light. Dentin is also able to transmit up to 30% of light. The esthetic dilemma for metal-ceramic restorations is that opaque porcelain is needed to mask a metal substrate. It will reflect light and decrease translucency. Consequently, they will often appear brighter intraorally [5, 135]. In-Ceram Spinnell had higher levels of translucency than In-Ceram Alumina (VITA Zahnfabrik), followed by In-Ceram Zirconia (VITA Zahnfabrik), which was comparable to a metal alloy .
Zirconia framework is esthetically better accepted than metallic framework, but it remains clinically too white and opaque. Therefore, manufacturers introduce colored zirconia framework to ameliorate the overall matching color . Different techniques have been proposed: adding pigments to the initial zirconia ceramic powder, dipping zirconia milled frameworks in dissolved coloring agents, applying liner material to sintered framework [69, 137]. Thinner veneer is then required to mask the underlying framework .
The ability to control the shade of the core may also eliminate the need to veneer the lingual and gingival aspects of the connectors in those situations where the interocclusal-distance is limited and the required connector dimensions are minimally achieved. In addition, the palatal aspect of anterior crowns and FPDs may be fabricated of the core material exclusively in situations of extensive vertical overlap and lack of space for lingual veneering porcelain [40, 139].
Individualized colored overpressed ceramics have been also proposed as a quick and easy technique . Excellent esthetic and perfect matching are difficult to attain, as appearance will rely on precolored ingots. To enhance esthetic, a layering ceramic can also be applied over an pressed-on veneer .
Lava system (3M ESPE Dental Products), which is relatively translucent but may still mask colored abutment, is proposed in 7 shades, permitting shading from the intaglio surface to the outer .
The increase of the concentration of the coloring pigments at grain boundaries could be at the expense of the stabilizing elements. This may result in higher percentage of tetragonal-monoclinic transformation. If this transformation occurs on the surface of the framework, this will provoke grain pullout and surface lifts . This phenomenon results from competitive displacement of the stabilizing elements by the metallic pigments in the liquid state. The latter have a melting point lower than the yetrium oxide one . A minor alteration of the location or the concentration of the stabilizing elements can alter the mechanical properties of the zirconia framework . A fatigue process started on individual surface areas will lead to monoclinic spots and results in surface microcracking and lifts. The color pigments at grain boundaries replacing the reduction of yttrium will affect the slowly extend of this process toward the bulk of the material [142, 143].
One study showed that the bond strength of colored zirconia is significantly lower compared to non-colored zirconia . When the framework is colored by dipping in pigment solution, the pigments will concentrate on the outer surface. Those surface pigments tend to crystallize on the surface and weaken the bond with the veneer ceramic .
Variable study conditions and plethora of materials available made the comparison of the results from relevant literature, a challenging issue . Usually, a failure in any clinical trial results from a combination of causes or events . Worth noting, there is a remarkable emphasis on clinical examination of the zirconia product , even though some of these studies lack scientific support . Reproducing intra-oral conditions, during the in vitro studies, is quite difficult. An effort was made to create artificial oral environments by applying cyclic forces in artificial saliva, under fluctuating temperature . Long-term clinical studies are still needed to make conclusions . In the era of evidence-based dentistry, reinforcing standardization of clinical cohort studies will permit more efficient conclusions . It has been noted that some granted research centers may be reluctant to publish bad results .
Concerns regarding metal-ceramic restorations biocompatibility limitations and optical qualities provoked the shift to all-ceramic restorations placement. While achieving marginal accuracies equal to that of metal-ceramic crowns, All-ceramic crowns provide superior gingival response .
Glass ceramic crowns, even those with a densely sintered alumina core, showed brittle fracture in the posterior region . Patient selection may be critical and the technique remains sensitive . Poor oral hygiene, high caries incidence, moderate gingival inflammation and severe parafunction are some of the exclusion criteria cited . A coping design allowing optimal ceramic layering thickness, a uniform cement film, and an adequate TEC matching between the laminate and the core may reduce the stresses .
Studies reported that zirconia ceramic flexure strength and fracture toughness are twice that of alumina ceramics . The partially stabilized tetragonal modification of zirconia to a monoclinic phase, induce by a tensile stress, exhibits 4% volume expansion. To propagate, the crack must overcome the compressive stresses generated at the crack tip [152, 153].
The aim of this review was not to evaluate survival and failure of different restorations. Authors agreed that Y-TZP can withstand physiologic functional loading forces and are comparable to metal-ceramic FPDs [27, 154]. Strength and marginal fit of zirconia ceramic has been confirmed by extensive laboratory testing [155, 156]. Still 5 to 10 year clinical studies are needed to determine primary mode of failure and success rate .
The major complication reported is chipping of the veneer with a rate that will increase from 6% to 10% between 3 and 5 years, whereas these values are reported on a 10 years observation period for metal-ceramic restorations [27, 55]. Fracture of the zirconia framework is not probable . Long-term success is essentially dependant of the performance of the veneering . Minor chip-off of the layering ceramic has been reported as the most frequent complication . Short-span posterior frameworks are reliable, whereas data is lacking for long span and cantilevers .
If bond failure has been pointed as chipping reason , differences in thermal coefficients , liner material and poor core wetting , veneer firing shrinkage [85, 86], phase transformation , loading stresses, flaw formation , coloring pigments  and surface properties  have been reported as potential causes. Upon fracture, similar to porcelain-alloys , a thin porcelain layer remained attached to the zirconia surface, showing that cohesive strength was lower than adhesive bond strength . Even scientific evidence was lacking, Fischer assumed that bond between zirconia and ceramic was chemical . Others go for mechanical interlocking added to cooling compressive stresses . The ability of zirconia to counteract crack propagation will result in a crack deflection . Framework design must provide uniform veneer support [14, 165, 166]. Pressable materials with an increase of the crystalline content generally improved the mechanical properties .
Ceramic crowns made only of zirconia, monolithic zirconia crowns, are not used widely in clinical practice because of the absence of a sound standard and the possibility of wear of the opposing teeth due to the hardness of zirconia .
Even if zirconia frameworks are preferred in posterior situations, compared to other allceram materials , some limitations still exist and proper diagnosis is critical for success  .
The quantity, size, and chemical properties of the crystals within the ceramic matrix will determine the opacity of a ceramic material . In-ceram Zirconia (VITA Zahnfabrik, Bad Sackingen, Germany) is reported the least translucent when compared to other ceramics [169, 170].
While success rate for 35% partially stabilized zirconia has been evaluated promising , long-term clinical data remain rare . The mechanical , esthetic , biocompatible , and metal-like radiopaque  properties allow the zirconia ceramics to be versatile, even though the opaque core limits their use in the anterior sextant . Careful patient selection and operating technique are essential. Bruxers, periodontally involved teeth exhibiting increased mobility, and cantilever prostheses are to be avoided . Fracture, located in the area between the retainer and pontic is the primary mode of failure. Under high tensile stress, it emanates from the gingival surface of the connectors, leading to catastrophic loss .
A framework design allowing for a uniform thickness and support of veneering porcelain has been shown to optimize the strength of bilayered specimens . Radial surface cracks can be generated by Intaglio wall adjustments of the framework, either with a 50 micron or coarser diamond rotary cutting instrument, and under dry or water cooling. This will compromise the strength of the zirconia core . Marginal fit has been reported similar to that of metal-ceramic restorations . Cementation of zirconia-based FPDs with either composite resin, glass ionomer, or resin-modified glass ionomer cements have been proposed, even long-term data are lacking [157, 174, 181].
Zirconia restorative material is well-placed to satisfy esthetic requirements and to fulfill functional requirements. Further studies should be conducted to resolve the complications that may reduce restorations longevity.
Within its limitations, this review has pointed some of the strengths and weaknesses of this promising material.
- Zirconia is able to withstand physiological posterior forces.
- Zirconia-veneer bonding is not yet well understood.
- Studies to reduce veneer chipping should be conducted.
- Ageing process, coloring pigments and liner materials have negative impact on the veneer- zirconia bond strength.
- Pressed veneer porcelain exhibit reduced fracture incidence compared to layered veneer.
- New compatible high strength ceramic veneers would reduce chip-off incidence.
- Framework design must provide anatomical support to the layer veneering ceramic.
Understanding each of these mechanisms will enhance the reliability of the zirconia as a multipurpose material.
CONFLICT OF INTEREST
The authors confirm that this article content has no conflicts of interest.