RESEARCH ARTICLE


CRP and IL-1B Gene Polymorphisms and CRP in Blood in Periodontal Disease



EI Auerkari1, 2, * , AW Suhartono1, NZ Djamal1, F Verisqa1, DA Suryandari3, LS Kusdhany2, 4, SLC Masulili5, C Talbot6
1 Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta Indonesia
2 Centre for Ageing Studies, University of Indonesia, Jakarta Indonesia
3 Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta Indonesia
4 Department of Prosthodontics, Faculty of Dentistry, University of Indonesia, Jakarta Indonesia
5 Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia
6 Department of Genetics, University of Leicester, UK


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© Auerkari et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Oral Biology, Faculty of Dentistry, University of Indonesia, Jakarta, Indonesia; Tel: +62213910344; Fax: +622131906289; E-mail: eauerkari@yahoo.com, elza.ibrahim@ui.ac.id


Abstract

Recent studies have suggested an association between periodontal disease (PD) and the systemic polygenic diseases such as cardiovascular disease (CVD). These are thought to be associated because of interrelated environmental, epigenetic, and genetic risk factors. The involved candidate genes include the IL-1B gene, encoding the pro-inflammatory cytokine IL-1β, and the CRP gene encoding the C-reactive protein (CRP), also a known marker of inflammation. However, as the details are not well known on the genetic variation influencing the risk factors, this work aimed to evaluate the distribution of selected polymorphisms of IL-1B and CRP genes, and serum CRP level, in comparison with the PD status. For this purpose, periodontal health was assessed, serum CRP levels measured and polymorphism status of IL-1B and CRP genes determined from samples of peripheral blood taken from 101 consenting Indonesian adult males. The results show that severe PD was significantly associated with age and smoking, as expected, but not with the polymorphisms of IL-1B or CRP (1444). However, a significantly lower fraction of subjects with normal periodontal health than subjects with PD showed the heterozygous type polymorphism of CRP (717). There was no significant difference in the fraction of cases with elevated serum CRP level between subjects with normal health and those with PD, and further study with a larger sample is recommended. The observed association between polymorphism of CRP (717) and periodontal health is suggested as a complementary indicator of the risk to PD for the Indonesian male population.

Keywords: Periodontal disease, cardiovascular disease, IL-1B, C-reactive protein, polymorphism, serum level.