Influence of Individual Saliva Secretion on Fluoride Bioavailability

E.A Naumova, P Gaengler, S Zimmer , W.H Arnold*
Department für Zahn-, Mund- und Kieferheilkunde, Universität Witten/Herdecke, Alfred Herrhausen Strasse 50, 58448 Witten, Germany

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© Naumova et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department für Zahn-, Mund- und Kieferheilkunde, Universität Witten/Herdecke, Alfred Herrhausen Strasse 50, 58448 Witten, Germany; Tel: +492302926658; Fax: +492302926661; E-mail:


The aim of this preliminary investigation was to compare the individual saliva secretion rate with the fluoride bioavailability in saliva after using sodium fluoride and amine fluoride.


To assess oral fluoride kinetics 10 highly trained volunteers brushed their teeth with one of the formulations and saliva was collected. The amount of saliva was measured, and the fluoride content was determined. Data underwent statistical analysis using the Mann-Whitney-U test and Pearson correlation. The ex vivo experiment I included individual saliva collection of the same volunteers. Then the oral hygiene products were solved in equal amounts of whole saliva (ex-vivo experiment II), and the fluoride content was measured. Finally, both products were dispersed in distilled water (ex-vivo experiment III) to calculate the dissociation of both products in water.


In vivo results of fluoride content after 3 min. tooth brushing demonstrated a negative correlation with saliva secretion: for NaF r = -0.695 (p<0.01) and for amine fluoride r = -0.446 (p<0.01). The in-vitro experiment I resulted for NaF in 251.7±22.4 µg/g fluoride and for amine fluoride in 171.7±14.4 µg/g.


Fluoride bioavailability of saliva after exposure to NaF was higher compared to amine fluoride. The individual secretion rate changes the fluoride content and normal secretors keep the fluoride availability longer.

Keywords: Fluoride, bioavailability, saliva, individual secretion, secretion rate, dentifrice.