An Analogy between Two Bio-Membranes (CGF-PRGF) Mixed with Xenogeneic Bone Graft to Achieve Frugal Management of Labial Dehiscence amidst Immediate Implantation in Esthetic Zone: A Randomized Clinical Trial

Labial dehiscence is a very prevalent esthetic concern among implantologists during immediate implantation in the esthetic zone since recent implant treatment and patient ambition are not only directed to function reestablishment, but esthetic superbness also holds immense consideration.

This study aimed to manage the labial dehiscence at the time of implantation and evaluate and compare the effects of two different autologous biomembranes, Concentrated Growth Factor (CGF) and Plasma Rich Growth Factors (PRGF), in combination with xenogeneic bone around the immediate implants in the esthetic zone.

Twenty patients indicated for immediate implant in the esthetic zone were randomly divided into two groups. The first group received CGF with xenograft, and the second group received PRGF mixed with xenograft. Cone Beam Computed Tomography (CBCT) radiographs and clinical periodontal parameters were evaluated, and all the results were tabulated and statistically analyzed.

The two groups showed a statistically significant increase in bone density and inevitable crestal bone loss after 9 months, even though the CGF group comparably showed a statistically significant reduction in crestal bone loss.

Platelet concentrate derivatives, such as CGF and PRGF, are beneficial in the management of labial dehiscence around the immediate implants even though CGF offers a considerably and statistically significant decrease in crestal bone loss and more amelioration of bone density alongside its easier and faster preparation than PRGF.

The study is registered at the U.S. National Library of Medicine website of clinical trials (clinicaltrials.gov) under ID: NCT05595772.