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The Cell Biocompatibility of a new Polycaprolactone-based Endodontics Sealer Compared with AH Plus Sealer
Simin Sharifi1
Authors Info & Affiliations
Abstract
Background:
One of the important materials needed for root treatment is the sealers. They fill the space between the gutta and the canal walls and create a suitable seal to prevent the colonization of oral microorganisms in the peri-apical tissues and inside the canal space.
Aim:
The aim of this study was to prepare and test the cell biocompatibility of a new polycaprolactone-based endodontics sealer in comparison to AH plus sealer against dental pulp stem cells.
Methods:
MTT assay was used to evaluate the cytotoxicity.
Results:
The results showed that AH plus showed moderate cytotoxicity effects against cells (the number of living cells was 49.45 ± 10.56%). However, for the new sealer, the number of living cells was ≥ 80% (81% ± 4.11). Thus, the sample was non-cytotoxic against tested cells.
Conclusion:
More investigations are needed on the new sealer to validate its biocompatibility and usefulness.
