The Effect of Zinc Lactate added Tablets on Volatile Sulfur-containing Compounds in the Oral Cavity
Pier F. Porciani1, *, Simone Grandini1
Identifiers and Pagination:Year: 2019
First Page: 405
Last Page: 409
Publisher Id: TODENTJ-13-405
Article History:Received Date: 15/07/2019
Revision Received Date: 28/08/2019
Acceptance Date: 20/10/2019
Electronic publication date: 28/11/2019
Collection year: 2019
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Oral malodor is defined as breath that is offensive to others and its prevalence is around 35%.
A controlled clinical double-blinded study was conducted to assess the efficacy of sugar-free tablets containing zinc lactate on oral Volatile Sulfur-containing Compounds (VSC) versus placebo tablets.
All participants, who met the inclusion criteria, had to score a level of VSC ≥75 ppb at the basal measurement. Subjects were randomly assigned to one of the groups. The test tablet (0.7g) contained 0.255 mg of zinc lactate; the control tablet was identical but without the active agent. The OralChroma2© device was utilized to evaluate VSC. The levels were recorded at baseline, after sucking two tablets in succession and after 1 hour and 2 hours. Data were analyzed with SPSS and significance was set at α=0.05.
186 subjects completed the trial. The mean reduction from baseline at the end of tablets sucking was, respectively, 43% (p <0.001) in the control and 67% (p <0.001) in the test group, after 1 hour, it was 6% in the control (p=NS) and 25% (p <0.001) in the test group, after 2 hours, it was 3% in the control (p=NS) and 12% (p <0.001) in the test group. The comparison between the two groups after baseline adjustment showed a statistically significant difference for reductions at the end of the sucking period (p <0.001), after 1 hour (p <0.001) and after 2 hours (p <0.05).
Tablets containing zinc lactate can statistically reduce the oral VSC levels immediately and for over 2 hours.