The Role of TNF-α as a Proinflammatory Cytokine in Pathological Processes
Luciano B. Silva1, Alexandrino P. dos Santos Neto2, *, Sandra M.A.S. Maia1, Carolina dos Santos Guimarães1, Iliana L. Quidute1, Alessandra de A.T. Carvalho2, Severino A. Júnior3, Jair C. Leão2
Identifiers and Pagination:Year: 2019
First Page: 332
Last Page: 338
Publisher ID: TODENTJ-13-332
Article History:Received Date: 26/12/2018
Revision Received Date: 11/07/2019
Acceptance Date: 25/08/2019
Electronic publication date: 30/09/2019
Collection year: 2019
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
TNF-α is a member of the vast cytokine family being considered a proinflammatory substance produced many by macrophages and other cells belonging to the innate immunity, many of them classified as indeed Antigen Presenting Cells (APCs) involved in the complex chemotactic process of activation of the adaptive immunity. The aim of this work was to accomplish a literature review concerning the main pathologies that have TNF-α as a modulating agent in other to bring light to the main interactions present in the inflammation installed.