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The Role of TNF-α as a Proinflammatory Cytokine in Pathological Processes
Luciano B. Silva1
Alexandrino P. dos Santos Neto2 , *
Sandra M.A.S. Maia1
Carolina dos Santos Guimarães1
Iliana L. Quidute1
Alessandra de A.T. Carvalho2
Severino A. Júnior3
Jair C. Leão2
Authors Info & Affiliations
Sandra M.A.S. Maia1
Carolina dos Santos Guimarães1
Iliana L. Quidute1
Alessandra de A.T. Carvalho2
Severino A. Júnior3
Jair C. Leão2
Authors Info & Affiliations
Abstract
TNF-α is a member of the vast cytokine family being considered a proinflammatory substance produced many by macrophages and other cells belonging to the innate immunity, many of them classified as indeed Antigen Presenting Cells (APCs) involved in the complex chemotactic process of activation of the adaptive immunity. The aim of this work was to accomplish a literature review concerning the main pathologies that have TNF-α as a modulating agent in other to bring light to the main interactions present in the inflammation installed.
Keywords: Tumor necrosis factor, Inflammation, Cytokine(s), Leucocytes, Antigen Presenting Cells (APCs), Interferon (IFN).
