Guided Implant Surgery to Reduce Morbidity in Von Willebrand Disease Patients: A Case Report

Mathilde Fénelon1, 2, Sabine Castet3, Jean-Christophe Fricain1, 2, Sylvain Catros1, 2, *
1 Department of Dentistry and Oral Health, University Hospital of Bordeaux, Bordeaux, France
2 Inserm U1026, BioIngénierie Tissulaire, University of Bordeaux, Bordeaux, France
3 Center for Inherited Bleeding Disorders (CRTH), University Hospital of Bordeaux, Bordeaux, France

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Creative Commons License
© 2018 Fénelon et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Dentistry and Oral Health, University Hospital of Bordeaux, Bordeaux, France; Tel: +33(0)557571115; Fax: +33(0)556900517; E-mail:



Von Willebrand Disease is the most common inherited bleeding disorder. In the general population, 1/8000 patients are affected. Primary hemostasis (platelet adhesion) and coagulation (protection of Factor VIII) are altered. Among several bleeding symptoms, these patients suffer from excessive bleeding of oral mucosa and dental management requires a close collaboration between haematologists and oral surgeons.

Materials & Methods:

Guided implant surgery can be used to increase the accuracy of implant placement and to reduce the overall morbidity of this surgical procedure by using a flapless surgery technique.

Case Report:

We report the case of a 49 years old woman having a Type 2A von Willebrand disease and who presented to replace tooth #.46 because of interradicular fracture and peri-apical infection. After planning the implant surgery using Codiagnostix® software, a surgical guide was prepared. The patient received 4 injections of von Willebrand factor (Willfactin®) for this particular surgical procedure. The implant was placed immediately after tooth removal and local haemostasis was performed.


The follow-up was uneventful and the implant was restored by a crown 4 months later. Two cases of implant placement in haemophiliac patients have been reported before in the literature.


As far as we know, this is the first case report of implant placement in a patient having a von Willebrand disease. The use of guided surgery allowed to perform a mini-invasive procedure and thus contributed to prevent bleeding complications in this patient.

Keywords: Dental implant, Oral surgery, Von Willebrand disease, Bleeding disorder, Hemostasis, Guided surgery.