Evaluation and Comparison of Total Antioxidant Capacity of Saliva Between Patients with Recurrent Aphthous Stomatitis and Healthy Subjects

Fatemeh Rezaei1, *, Taher Soltani2
1 Department of Oral Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran

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Creative Commons License
© 2018 Rezaei and Soltani.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Oral Medicine, Kermanshah University of Medical Sciences, School of Dentistry, Shariati street, Kermanshah, Iran; Tel : +98-918-8371081; E-mail:


Background & Objectives:

Recurrent Aphthous Stomatitis (RAS) is one of the most common chronic ulcerative lesions of the oral mucosa and its development may be associated with oxidative stress. The aim of this study was to evaluate salivary Total Antioxidant Capacity (TAC) in patients with minor RAS.

Materials & Methods:

In this case-control study, 27 patients with minor RAS and 28 age- and sex-matched controls without RAS were enrolled. TAC was measured in unstimulated saliva for patients (during active lesion phase and after healing) and controls by immunologic assay. Data were analyzed by SPSS 18 using paired and unpaired t-tests (P<0.05).


Salivary TAC levels of patients presented a significant increase from active lesion phase (0.26±0.16) to healing time (0.43±0.41); (P=0.034). There was no significant difference in the level of salivary TAC between patients during active lesion phase and controls (0.24±0.13); (P=0.641).


Increasing level of salivary TAC may be involved in remission of RAS lesions, suggesting its evaluation in future studies.

Keywords: Recurrent aphthous stomatitis, Saliva, Total antioxidant capacity, Inflammatory lesions, Erythematous margin, Oxidative stress.