Osseointegration of Dental Implants in a Patient with Hajdu-cheney Syndrome

Panagiota Dokou1, *, Ioannis K. Karoussis1, George Papavasiliou2, Phophi Kamposiora2, Theophilos P. Vrahopoulos3, John A. Vrotsos1
1 Department of Periodontology, School of Dentistry, University of Athens, Greece
2 Department of Prosthodontics, School of Dentistry, University of Athens, Greece
3 Private Practice, 10 Monis Petraki Str, Evaggelismos, Athens 11521, Greece

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© Dokou et al.; Licensee Bentham Open

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Periodontology, School of Dentistry, University of Athens, 2 Thivon Str, Goudi, Athens, 11527 GR, Greece; Tel: 0030210 7461203; Fax: 0030210 7461202; E-mail:



Hajdu-Cheney Syndrome (HCS) is a rare hereditary bone metabolism disorder characterized by acro-osteolysis, short stature, craniofacial changes, periodontitis and premature tooth loss. Extensive search of the current literature revealed no reports of implant placement in patients with HCS.

Case Report:

A 22-year old woman with osteoporosis, generalized advanced chronic periodontitis and premature tooth loss was referred to the Postgraduate Clinic of Periodontology, University of Athens-Greece. The patient was diagnosed in 2001 with HCS. The patient received non-surgical periodontal treatment and several teeth were extracted due to extensive alveolar bone loss.

After careful consideration of the possible implications deriving from the patient’s condition and having taken her young age into account, initially, a dental implant was placed in the upper right first premolar region. Specific protocols such as longer healing periods were implemented, so five years after placement and successful osseointegration of this implant, four additional dental implants were placed in the posterior regions of the maxilla and the mandible. Prosthetic rehabilitation followed 6 months after implant placement. Upon completion of periodontal treatment, the patient was enrolled in a periodontal maintenance program.


Clinical and radiographic examination of the patient during the periodontal maintenance program after implant placement revealed no abnormalities in the implant region.


Patients with HCS suffer from periodontitis, bone destruction and premature tooth loss. This case indicates the successful osseointegration of dental implants in patients with HCS. However, further research is required in order to determine the predictability of dental implant placement in those patients.

Keywords: Acro-osteolysis, Dental implants, Hajdu-cheney syndrome, Osteoporosis, Periodontitis.