Diagnosis and Intralesional Corticotherapy in Oral Ulcers Occurring as the Sole Manifestation of Langerhans Cell Histiocytosis. A Case Report

Liane Gambirazi, Tatiana Libório, Fábio Nunes, Norberto Sugaya, Dante Migliari*
Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil

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© Gambirazi et al; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Universidade de São Paulo, Faculdade de Odontologia, Departamento de Estomatologia, Av: Prof. Lineu Prestes, 2227 - Cidade Universitária, São Paulo, SP 05508-900, Brazil; Tel/Fax: +55 11 30917901; E-mail:


This article reports a case of oral mucosa lesions as the sole manifestation in Langerhans cell histiocytosis (LCH). This is a very uncommon manifestation of LCH since this disease preferably affects the bones with frequent involvement of the jaws. LCH may also involve other organs, particularly the lungs, liver, lymph nodes, and skin. The highlights of this report are the differential diagnosis, immunohistochemical analysis and, mostly, the therapeutic approach.

Keywords: Diagnosis, Intralesional corticotherapy, Langerhans cell histiocytosis, Oral ulcers.