Manifestations in the Oral Mucosa of Erythromelalgia. A Case Report

N López-Valverde1, A López-Valverde1, *, J Ramírez 2, R Gómez de Diego3
1 Department of Surgery, Faculty of Medicine, School of Dentistry, University of Salamanca, Spain
2 Department of Morphological Sciences. School of Medicine, University of Córdoba, Spain
3 Department of Stomatology, School of Odontology, University Rey Juan Carlos, Madrid, Spain



Erythromelalgia or erythermalgia, is a peripheral paroxysmal vascular disease of the distal extremities, although it can also affect the face, ears and knees. It is characterized by increased skin temperature, erythema and intermittent episodes of burning pain. Likewise, it can also be characterized by lesions of the oral mucosa.

Case report:

Here we present the case of a 6-year old female with EM presenting ulcerative and scaly lesions in the oral cavity and whitish linear branching ulcerative lesions on the tongue. Fabry disease and rheumatoid conditions were ruled out and there were no mutations in SCN9A gene. Treatment with voltage-gated sodium channel blockers (oxcarbacepine-Trileptal®) and anticonvulsants (Perampanel-Fycompa®) did not improve pain symptoms, however, performing moderate physical activity, use of comfortable footwear, and local application of cold resulted in the restoration of patient´s quality of life


To our knowledge, this report described for the first time, the successful treatment of ulcerative lesions of the oral mucosa in Erythromelalgia. We believe that the treatments described here (exercise, comfortable footwear and local application of cold) could improve the quality of life of Erythromelalgia patients.

Keywords: Erythromelalgia, Erythermalgia, Ulcerative lesion, Whitish lesion, Oral mucosa.

Abstract Information

Identifiers and Pagination:

Year: 2019
Volume: 13
Publisher Item Identifier: EA-TODENTJ-2018-145

Article History:

Received Date: 20/11/2018
Revision Received Date: 2/01/2019
Acceptance Date: 24/1/2019
Electronic publication date: 07/02/2019
Collection year: 2019

© 2019 López-Valverde et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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