TODENTJ-25-03-2019_TODENTJ-9-388
1553505905
Bentham Open
doi@benthamopen.net
Bentham Open
The Open Dentistry Journal
TODENTJ
1874-2106
12
11
2015
9
1
Inhibitory Effect of Alpha-Mangostin on Adhesion of Candida albicans to
Denture Acrylic
Ruchadaporn
Kaomongkolgit
Kusuma
Jamdee
Objective: Candida-associated denture stomatitis is a very
common disease affecting denture wearers. It is characterized by the presence of
yeast biofilm on the denture, primarily associated with C. albicans. The
investigation of agents that can reduce C. albicans adhesion may
represent a significant advancement in the prevention and treatment of this
disease. This study aims to investigate the effect of alpha-mangostin on the
in vitro adhesion of C. albicans to denture acrylic and germ tube
formation by C. albicans and to compare its activity with clotrimazole
which is a topical antifungal agent commonly used for the treatment of
Candida-associated denture stomatitis. Materials and Methodology:
Alpha-mangostin was extracted by thin layer chromatography. The effect of alpha-mangostin
on adhesion of C. albicans to denture acrylic was determined by using a
colorimetric tetrazolium assay and germ tube formation by C. albicans was
determined by using the counting chamber. Results: A significant
reduction of C. albicans adhesion to denture acrylic was evident after
exposure to 2,000 µg/ml of alpha-mangostin for only 15 min. In addition, the
2,000 µg/ml of the alpha-mangostin-treated C. albicans had a reduced
ability for germ tube formation. These inhibitory effects of alpha-mangostin
were as effective as clotrimazole. Conclusion: Alpha-mangostin has
antifungal property against C. albicans by inhibiting the adhesion to
denture acrylic and germ tube formation in vitro. These results suggest
the potential application of alpha-mangostin as a topical medication or a
natural oral hygiene product for treatment of Candida-associated denture
stomatitis.
12
11
2015
388
392
TODENTJ-9-388
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1553505905
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