TODENTJ-25-03-2019_TODENTJ-9-340 1553505887 Bentham Open doi@benthamopen.net Bentham Open The Open Dentistry Journal TODENTJ 1874-2106 7 31 2015 9 1 Gita Rezvani Mandana Donoghue Peter A Reichart Neda Pazuhi A 24 year-old male was presented for the diagnosis of an asymptomatic bony expansion in relation to the right maxillary canine and first premolar. The unilocular radiolucent lesion with central foci of calcification had caused divergence of canine and first premolar roots without any resorption. This case report details a diagnosis of two distinct disease processes of different cellular origin namely, focal cemento-ossifying dysplasia and adenomatoid odontogenic tumor in a previously unreported concomitant and contiguous relationship. The diagnosis was determined by a combination of clinical, radiographic, histopathological and surgical evidence. This case highlights two points, first the need to examine all mixed radiolucent-radiopaque lesions with advanced imaging techniques to assess the number and extent of the lesions prior to treatment planning. Second a likely role of periodontal ligament as the tissue source for odontogenic epithelial cells and mesenchymal stem cells required for the development of odontogenic tumors and cemento-osseous dysplasias. 7 31 2015 340 345 TODENTJ-9-340 1 10.2174/crossmark_policy opendentistryjournal.com benthamopen.com true Peer Reviewed Single blind Checked with iThenticate 2014-12-20 2015-3-19 2015-5-25 2015-7-31 http://creativecommons.org/licenses/by-nc/3.0/ 10.2174/1874210601509010340 1553505887 https://opendentistryjournal.com/VOLUME/9/PAGE/340/ https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-340/TODENTJ-9-340.pdf https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-340/TODENTJ-9-340.pdf https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-340/TODENTJ-9-340.pdf https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-340/TODENTJ-9-340.pdf https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-340/TODENTJ-9-340.pdf https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-340/TODENTJ-9-340.pdf https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-340/TODENTJ-9-340.pdf https://opendentistryjournal.com/contents/volumes/V9/TODENTJ-9-340/TODENTJ-9-340.xml Eversole L. 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